PROSTACYCLIN PRODUCTION BY HUMAN UMBILICAL VEIN ENDOTHELIUM IN RESPONSE TO SERUM FROM PATIENTS WITH SYSTEMIC SCLEROSIS |
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| Authors: | HOLT, C. M. MOULT, J. LINDSEY, N. HUGHES, P. GREAVES, M. ROWELL, N. R. |
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| Affiliation: | University Department of Medicine, Northern General Hospital Sheffield
*University Department of Haematology, Royal Hallamshire Hospital Sheffield
!["{dagger}"]("/math/dagger.gif") University Department of Dermatology, General Infirmary at Leeds Leeds |
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| Abstract: | Sera from 29 patients with systemic sclerosis and 30 normalcontrols were examined for their effect on prostacyclin releaseby human umbilical vein endothelial cells during periods ofresponse of 15 min and 72 h and for their effect on endothelialgrowth and 3H-thymidine uptake during a 72-h culture period.In contrast to previous reports, no significant differenceswere detected between patient and control sera in their effecton endothelial cell prostacyclin release, growth or 3H-thymidineuptake. KEY WORDS: Scleroderma, Endothelial cells, Blood vessels, Prostanoid metabolism |
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