Effect of intravenous ketanserin on the human action potential duration at fixed heart rate |
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Authors: | Angela J Drake-Holland Mark I M Noble Sara Pugh Christopher Mills |
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Institution: | (1) Department of Medicine 1, St, George's Hospital Medical School, London;(2) King Edward VII Hospital, Midhurst, West Sussex;(3) Department of Medicine, Charing Cross and Westminster Medical School, London, England;(4) Department of Medicine 1, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE London, England |
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Abstract: | Summary In this study any changes in action potential duration or Q-T interval due to acute doses of ketanserin were monitored. The effect of a bolus dose (10 or 20 mg) followed by an infusion (10 or 20 mg over 20 minutes) of ketanserin on the Q-T interval and action potential duration was studied in six patients undergoing routine cardiac catheterization. Action potential duration was measured with a silver-silver chloride electrode catheter while heart rate was kept constant by atrial pacing and reflex effects avoided by -adrenergic blockade. There were some prolongations of the action potential duration but they were not in excess of 40 msec and did not reach statistical significance (control 263±46.0 msec; bolus 269±52.1 msec; infusion 262±53.6 msec; nor were there any significant changes in Q-T interval. Thus acute intravenous doses of ketanserin, in the absence of hypokalaemia or other Q-T interval-prolonging drugs, have no consistent effect on Q-T interval or action potential duration; prolongation of the action potential, when it occurs, is small. |
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Keywords: | action potential in man Q-T interval ketanserin serotonin antagonist |
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