| 血、尿内皮素水平与肾性高血压的研究 |
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| 引用本文： | 石蕾 单若明 等. 血、尿内皮素水平与肾性高血压的研究[J]. 首都医科大学学报, 2001, 22(2): 135-137 |
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| 作者姓名： | 石蕾 单若明 等 |
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| 作者单位： | [1]首都医科大学附属北京天坛医院肾内科 [2]首都医科大学检测中心 |
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| 摘 要： | 为探讨血、尿内皮素水平在肾性高血压及肾脏疾病发展中所起的作用 ,对正常人和慢性肾炎患者血浆内皮素 (PET 1 )、2 4h尿内皮素排泄量 (UET 1 )、内生肌酐清除率 (Ccr)和尿 β2 微球蛋白 ( β m)进行了检测。结果显示所有患者的PET 1和UET 1水平均升高 ,且PET 1或UET 1与平均动脉压 (MAP)和β m呈正相关 ,与Ccr呈负相关。提示 :血、尿内皮素均参与肾性高血压形成和肾脏病的进展
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| 关 键 词： | 肾性高血压 内皮素 内生肌酐清除率 β2-微球蛋白 |
| 收稿时间： | 2000-11-20 |
| 修稿时间： | 2000-11-20 |
Study on Plasma Levels ofEndothelin-1 and Urinary Excretion Rate of Endethlin in Chronic GlomerulonephritisPatients with Renal Hypertension |
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| Shi Lei,Zhao Yiwen,Zhang Xiaoping. Study on Plasma Levels ofEndothelin-1 and Urinary Excretion Rate of Endethlin in Chronic GlomerulonephritisPatients with Renal Hypertension[J]. Journal of Capital Medical University, 2001, 22(2): 135-137 |
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| Authors: | Shi Lei Zhao Yiwen Zhang Xiaoping |
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| Affiliation: | Shi Lei,Zhao Yiwen,Zhang Xiaoping Department of Nephrology,Beijing Tiantan Hospital,Affiliate of Capital University of Medical Sciences Shan Ruoming Clinic Analysis Laboratory,Capital University of Medical Sciences |
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| Abstract: | To elucidate the effects on renal hypertension and progressive renal disease of endothelin 1 in patients of chronic glomerulonephritis, plasma endothelin 1(PET-1), urinary excretion rate of endothelin 1(UET-1), creatinine clearance(Ccr)and urinary excretion rate of β2- microglobulin(β-m)in 54 patients with chronic glomerulonphritis and those in 20 normal control were measured. The Results indicated the level of PET-1 and UET-1 in all patients was markedly elevated. There was a positive correlation between PET-1 or UET-1 and mean ertery pressure(MAP)and a negative relation between the former and β-m. Correlation between PET-1 or UET-1 and Ccr were found. Endothelin plays an important role in developing renal hypertension and in porgressive renal disease and also UET-1 is a sensitive marker of renal tubular damage. |
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| Keywords: | renal hypertension endothelin creatinine clearance β2-microglobulin')" href=" #" >2-microglobulin |
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