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Prenatal diagnosis of neural tube defects: VIII. The importance of serum alpha-fetoprotein screening in diabetic pregnant women |
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| Authors: | Aubrey Milunsky Elliot Alpert John L. Kitzmiller M.Donna Younger Raymond K. Neff |
| Affiliation: | 1. Departments of Pediatrics, Medicine, and Obstetrics and Gynecology, Harvard Medical School, USA;2. Genetics Division, Eunice Kennedy Shriver Center, USA;3. Brigham and Women''s Hospital, USA;4. Joslin Clinic, USA;5. Health Sciences Computing Facility, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA |
| Abstract: | Maternal serum alpha-fetoprotein (AFP) screening of routine pregnancy is a valuable tool for the prenatal detection of neural tube defects (NTDs). Against our background experience with >24,000 screened pregnancies, we have studied 411 pregnant insulin-dependent diabetic women. More than a tenfold increase (19.5/1,000) in the frequency of NTDs was observed m the offspring of these diabetic patients (p < 0.000001). Serum AFP values were tower in diabetic than in nondlabetic women. Our data indicate that the normal standard of care for diabetic pregnancy should include serum AFP screening. |
| Keywords: | Reprint requests: Dr. Aubrey Milunsky Center for Human Genetics B.U.S.M. 80 E. Concord St. Boston Massachusetts 02118 |
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