强迫症患者的执行功能与部分临床特征的相关性分析

目的：探讨强迫症患者的执行功能与部分临床特征的相关性。方法筛选106例强迫症患者入组，采用韦氏木块拼图、连线试验A＆amp;B、威斯康星卡片分类测验（WCST）评估患者执行功能，Y-BOCS量表中文版和HAMD及自制调查问卷评价患者临床症状。结果男女患者的执行功能各项指标差异无统计学意义；患者的连线试验A时间与强迫思维分、强迫行为分及Y-BOCS总分均呈线性正相关，连线试验B时间与Y-BOCS总分呈线性正相关（P〈0.05）；强迫行为分及Y-BOCS总分与WCST完成分类数呈线性负相关（P〈0.05），Y-BOCS总分与总错误数呈线性正相关（P〈0.05）；病程与WCST持续错误数之间呈线性正相关（P〈0.05）；患者的韦氏积木分数与患者Y-BOCS各项分数、发病年龄、病程、总治疗时间之间呈负相关，但无线性关系（P〉0.05）。结论强迫症的执行功能障碍与其临床症状严重程度明显相关，与患者性别、发病年龄、病程、疾病严重度等关系不大，但病程越长， WCST持续错误数越多。

Association analysis between executive function and some clinical features in obsessive-compulsive disorder

Objective To explore the correlation of the executive function and clinical features in patients with obsessive-compulsive disorder （OCD）. Method Screened 106 OCD patients into the research group, Wechsler Block Design Subtest （WISC：BD）, Trail-Making Test A＆amp;B, Wisconsin Card Sorting Test （WCST）, were used to as-sess the executive function of the patients with OCD, Yale-Brown Obsessive Compulsive Scale （Y-BOCS） and Hamil-ton Depression Scale （HAMD） were employed to evaluate the OCD and depressive symptoms, respectively. A clinical and demographic information questionnaire was used to record the patients＇ clinical datas. Results All indicators of executive function in male and female patients revealed no statistically significant difference. Trail-Making test A （time） in OCD patients have a positive correlation with the score of obsession and compulsion and Y-BOCS, Trail-Making test B （time） of patient with OCD have a positive correlation with the score of Y-BOCS （P〈0.05）. But negative linear correlations were found between the score of Y-BOCS and the accomplished classifications of WCST （P〈0.05）. There were positive correlations between the course and WCST total errors （P〈0.05）. Negative correlations were found between Y-BOCS scores and age of onset and course and the duration of treatment, but no linearity rela-tionship （P〉0.05）. Conclusion There were significantly correlations between damage of executive function in OCD patients and severity of the symptoms, The study showed that gender, onset age,course and severity of disease were no ignificantly relationship with the damage of executive function in OCD, but the longer the course, the more WCST total errors.