| 离子色谱法测定伏格列波糖片的溶出度 |
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| 引用本文： | 楼永明,陈军. 离子色谱法测定伏格列波糖片的溶出度[J]. 海峡药学, 2014, 26(1): 62-63 |
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| 作者姓名： | 楼永明 陈军 |
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| 作者单位： | 楼永明 (福建省药品检验所,福州,350001)； 陈军(赛默飞世尔科技中国有限公司,广州,510000)； |
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| 摘 要： | 目的 建立离子色谱法测定伏格列波糖片的溶出度.方法 分析柱：CarboPac MA1分离柱（4×250mm）,淋洗液：50mmol·L-1NaOH,流速：0.4mL·min-1,柱箱温度：35℃,进样量：50μL,检测方式：电化学检测器.结果 在0.4μg·mL^-1～4μg·mL-1μg·mL-1浓度范围内与峰面积呈良好的线性关系,r=0.9977,平均回收率为100.6%,RSD为1.0% （n=9）.结论 该方法快速,准确.
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| 关 键 词： | 溶出度 伏格列波糖片 离子色谱法 |
Determination of content for Volibose Tablets Dissolution by Ion Chromatography |
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| LOU Yong-ming,CHEN Jun. Determination of content for Volibose Tablets Dissolution by Ion Chromatography[J]. Strait Pharmaceutical Journal, 2014, 26(1): 62-63 |
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| Authors: | LOU Yong-ming CHEN Jun |
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| Affiliation: | 1. Fujian institute for drug control Fuzhou 350001, China;2. Thermo Fisher technlolgies China Ltd, guangzhou 510000, China) |
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| Abstract: | OBJECTIVE To establish the Ion chromatography method for the determination of Dissolution for Voglibose Tablets. METHODS The analytical column was CarboPac MAI （4 ×：250mm） and the leacheate was 50mmol · L-1 sodium hydrate at a flow rate of 0. 4mL ·min-1. The temperature of column was 35℃. RESULTS The calibration curve of Voglibose was performed over the range of 0. 4μg·mL^-1 ~4μg·mL^-1 ,r =0. 9977. The av- erage recovery was 100. 6% and RSD was 1.0%. CONCLUSION The method is accurate and rapid. |
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| Keywords: | Dissolution Volibose Tablets Ion chromatography |
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