强化期含左氧氟沙星方案治疗肺结核合并糖尿病疗效观察

目的 探讨强化期含左氧氟沙星方案治疗肺结核合并糖尿病的疗效及安全性.方法 随机将96例肺结核初治合并2型糖尿病患者分为两组,两组患者均给予2～3HRZE/6～9HR抗结核治疗,治疗组51例在强化期加用左氧氟沙星片0.3qd治疗2～3月.观察两组患者治疗疗效及不良反应.结果 治疗组治疗3月时肺部病灶吸收、痰菌转阴率均明显好于对照组（P＜0.05）;两组患者治疗中不良反应发生率无明显差异（P＞0.05）.结论 对于肺结核合并糖尿病患者,强化期加用左氧氟沙星治疗,可加快病灶吸收速度,及痰菌转阴速度,未明显增加不良反应发生率.

Observation on curative effect of a scheme with Levofloxacin in the intensive phase treatment of pulmonary tuberculosis accompanied with diabetes mellitus

OBJECTIVE To explore the curative effect and the security of sublingual levofloxacin in the inten- sive phase treatment of initial smear-positive pulmonary tuberculosis accompanied with diabetes mellitus. METHODS Ninety-six patients with initial smear-positive pulmonary tuberculosis accompanied with type 2 diabetes mellitus were randomly divided into two groups, both of which were given 2 ~ 3HRZE/6 ~ 9HR for antituberculosis thera- py. The treatment group （51 patients） during the intensive phase was treated with extra levofloxacin 0. 3g qd for 2 to 3 months. Curative and untoward effects were observed for both groups. RESULTS After 3-month treatment, both absorption rate of pulmonary lesion and sputum negative conversion rate in the treatment group were significantly bet- ter than these in the control group （ P 〈 0.05 ） ; no significant difference in incidence of untoward effect was found be- tween both groups in the treatment （ P 〉 0. 05 ）. CONCLUSION For patients with pulmonary tuberculosis accom- panied with diabetes mellitus, extra use of levofloxacin during the intensive phase treatment can accelerate the absorp- tion of the lesions and the sputum negative conversion without a marked increase in the incidence of untoward effect.