| 卡培他滨片溶出度的方法学研究 |
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| 引用本文： | 费梦莹,廖声华,孙晓娟,严拯宇.卡培他滨片溶出度的方法学研究[J].海峡药学,2014,26(1):50-52. |
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| 作者姓名： | 费梦莹 廖声华 孙晓娟 严拯宇 |
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| 作者单位： | 费梦莹(中国药科大学分析化学教研室,南京,211198国家药物质量与安全预警教育部重点实验室,南京,210009)；廖声华(中国药科大学分析化学教研室,南京,211198国家药物质量与安全预警教育部重点实验室,南京,210009)；孙晓娟(中国药科大学分析化学教研室,南京,211198国家药物质量与安全预警教育部重点实验室,南京,210009)；严拯宇(中国药科大学分析化学教研室,南京,211198国家药物质量与安全预警教育部重点实验室,南京,210009)； |
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| 摘 要： | 目的 建立卡培他滨片的溶出度测定法.方法 采用紫外分光光度法测定卡培他滨片的溶出量.结果 在检测波长304nm,样品浓度在1.693μg·mL-1～33.86μg·mL^-1范围内线性良好,r=0.9999（n=6）;平均加样回收率为102.2%（RSD=0.72%）.结论 该方法操作简单,迅速,结果准确,可用于卡培他滨片的溶出度测定.
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| 关 键 词： | 紫外分光光度法 卡培他滨片 溶出度 |
Studies on the method for determination of solubility of Capecitabine tablets |
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| FEI Meng-ying,LIAO Sheng-hua,SUN Xiao-juan,YAN Zheng-yu.Studies on the method for determination of solubility of Capecitabine tablets[J].Strait Pharmaceutical Journal,2014,26(1):50-52. |
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| Authors: | FEI Meng-ying LIAO Sheng-hua SUN Xiao-juan YAN Zheng-yu |
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| Institution: | 1. China Pharmaceutical uni- versity, Nanjing 211198, China ;2. Key Laboratory of Drug Quanlity Control and Pharmacovigliance of Minis- try of Education, Nanjing 2]0009,China) |
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| Abstract: | OBJECTIVE To set a method for determination of solubility of Capecitabine Tablets. METHODS Solubility of Capecitabine Tablets was determined by UV. RESULTS The wavelength used in determination was 304nm. The calibration was line in concentration range of 1. 693μg·mL^-1- 33.86 μg·mL^-1 , r = 0. 9999 （ n = 6 ） ; The average recovery was 102.2% （ RSD = 0. 72% ）. CONCLUSION The methods in the article was simple and rapid, excellent precision, which can be used as the index of dissolutions. |
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| Keywords: | UV Capecitabine Tablets Solubility |
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