微创血肿穿刺术后联合依达拉奉对高血压脑出血疗效和认知功能及血清炎性因子水平的影响

目的 探讨微创血肿穿刺术后联合依达拉奉对高血压脑出血疗效和认知功能及血清炎性因子水平的影响.方法 选取雅安市人民医院于2014年6月-2016年6月收治的90例高血压脑出血.按照治疗方法分为对照组与观察组,每组45例,对照组给予微创血肿穿刺术与常规治疗,观察组在对照组基础上联合依达拉奉治疗.对比两组临床疗效、中国脑卒中临床神经功能缺损程度评分量表(CSS)评分、蒙特利尔认知评估量表(MoCA)评分、血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平.结果 观察组临床总有效率明显高于对照组(P＜0.05).治疗后14 d和28 d,两组CSS评分、hs-CRP、TNF-α和IL-6水平均低于治疗前(P＜0.05),且观察组上述指标低于对照组(P＜0.05).治疗后14 d和28 d,两组MoCA评分均高于治疗前(P＜0.05),且观察组MoCA评分高于对照组(P＜0.05).结论 微创血肿穿刺术联合依达拉奉治疗高血压脑出血可获得显著效果,促进神经功能的恢复,降低血清炎性因子水平.

Effects of Combination of Edaravone after Minimally Invasive Hematoma Puncture on Curative Effect of Hypertensive Cerebral Hemorrhage,Cognitive Function and Serum levels of Inflammatory Factors

Objective To analyze effects of combination of Edaravone after minimally invasive hematoma puncture on curative effect of hypertensive cerebral hemorrhage,cognitive function and serum levels of inflammatory cytokines.Methods A total of 90 patients with hypertensive cerebral hemorrhage admitted during June 2014 and June 2016 were divided into control group and observation group according to different treatment methods (n =45 for each group).Control group was given minimally invasive hematoma puncture and conventional treatment,while observation group was added Edaravone on the basis of treatment for control group.Clinically curative effect,Chinese stroke clinical neurological impairment scale (CSS) score,Montreal cognitive assessment scale (MoCA) score,serum hypersensitive C-reactive protein (hs-CRP),tumor necrosis factor-alpha (TNF-o) and interleukin-6 (IL-6) levels were compared in two groups.Results The total effective rate in observation group was significantly higher than that in control group (P ＜ 0.05).After treatment for 14 d and 28 d,CSS scores,hs-CRP,TNF-α and IL-6 levels were significantly lower than those before treatment in two groups (P ＜ 0.05),and the above indexes in observation group were significantly lower than those in control group (P ＜ 0.05);MoCA scores were significantly higher than those before treatment in two groups (P ＜ 0.05),and the MoCA score in observation group was significantly higher than that in control group (P ＜ 0.05).Conclusion Combination of Edaravone after minimally invasive hematoma puncture in treatment of hypertensive cerebral hemorrhage can achieve well curative effect,promote neurofunctional recovery and reduce levels of serum inflammatory factors.