冠心宁对不稳定型心绞痛患者血栓素A2与前列环素比值的影响

目的：通过测定血栓素A2（TXA2）与前列环素（PGi2）代谢产物TXB2、6-酮前列腺素（Keto—PGF）1α水平及其比值（TXB2／6-Keto—PGF1α，T／K），观察冠心宁注射液对不稳定型心绞痛（UAP）患者TXA2与PGI2比值的影响。方法：120例冠心病UAP患者被随机分为冠心宁组和常规治疗组。另选60例健康老年人作为正常对照组。治疗前和治疗后2周分别测定TXB2，6-Keto—PGF1α水平，计算T／K比值。结果：UAP患者血浆TXB2、T／K明显高于正常对照组（216．13±89．86）pg／ml：（78．2±19．4）pg／ml，（3．19±0．78）：（0．57±0．13）]，而6-Keto-PGF1α明显低于正常对照组（67．02±21．63）pg／ml：（112．4±26．14）pg／ml，P均〈0．01]。常规治疗组和冠心宁组治疗后6～Keto—PGFlα均明显升高（P〈0．05，P〈0．01），TXB2、T／K比值明显下降（P均〈O．01），与常规治疗组相比，冠心宁组治疗后6-Keto-PGF1α水平显著升高（80．2±26．3）pg／ml：（109．1±23．9）pg／ml，P〈0．013，TXB2、T／K比值显著下降（123．5±34．2）pg／ml：（100．5±35．6）pg／ml，（1．59±2．66）：（0．91±0．17），P〈0．05～0.01]。结论：冠心宁注射液可减少TXA2的生成，促进PGI2分泌．纠正TXA2／PG它比值失衡，这可能是其治疗不稳定型心绞痛的机制。

Effect of Guanxinning injection on the ratio between thromboxane A2 and prostacyclin I 2 in patients with unstable angina pectoris

Objective： To study the effect of Guanxinning injection on the ratio between thromboxane A2 matabolic product TXB2 and prostacyclin I 2 metablic product 6-Keto-PGF1α in patients with unstable angina peetoris （UAP） Methods： A total of 120 UAP patients were divided into 2 groups： Guanxinning injection therapy group, conventional therapy group. Another 60 normal persons were regard as normal control group, The levels of TXB2, 6- Keto - PGF1α, and TXB2/6-Keto-PGF1α （T/K） were tested before treatment and 2- week after treatment. Results： The levels of TXB2 and T/K were significantly higher （216. 13±89.86） pg/ml vs. （78.2±19.4） pg/ml, （3. 19± 0.78） vs. （0. 57±0.13）], and 6- Keto-PGF1α was significantly lower （67.02 ± 21.63） pg/ml vs. （112.4± 26.14） pg/ml] in patients with UAP than those of normal control group, P〈0.01 all. The level of 6-Keto-PGF1α significantly increased after therapy in conventional therapy group and Guanxinning injection therapy group （P〈0. 05, P〈0. 01 respectively）, the levels of TXB2 and T/K after treatment significantly decreased in these two groups （P〈 0. 01 26.3 34.2） ] Compared with conventional therapy group, the level of 6-Keto-PGFla significantly increased （80. 2 ±26.3 pg/ml vs. （109.1±23.9） pg/ml, P（0.01], the levels of TXB2 and T/K significantly decreased - （123.5± 34.2）pg/ml vs. （100.5±35.6） pg/ml, （1. 59±2.66） vs. （0. 91±0.17）, P（0.05, P〈0. 01 respectively]. Conclusion： Guanxinning injection can reduce production of TXA2; promote secretion of PGI2, and improve T/K ratio, thus it may be mechanism of coronary artery disease.