铁代谢与冠状动脉狭窄的相关性分析

目的:探讨铁代谢相关指标与冠心病(CHD)病人冠状动脉狭窄的相关性.方法:选取94例CHD病人作为观察组,非CHD病人94例作为对照组,检测其铁代谢相关指标血清铁蛋白(SF)、总铁结合力(TIBC)、SF/TIBC水平并进行分析.结果:观察组SF、SF/TIBC显著高于对照组,TIBC显著低于对照组(P<0.01).冠状动脉轻度狭窄组、中度狭窄组、重度狭窄组之间SF、TIBC、SF/TIBC差异均有统计学意义(P<0.01),两两比较显示,重度狭窄组SF、SF/TIBC高于中度狭窄组、轻度狭窄组,TIBC低于中度狭窄组、轻度狭窄组(P<0.05和P<0.01);中度狭窄组SF/TIBC显著高于轻度狭窄组,TIBC显著低于轻度狭窄组(P<0.01).CHD病人Gensini评分与SF、SF/TIBC呈显著正相关关系(r=0.419、0.624,P<0.05),与TIBC呈显著负相关关系(r=-0.347,P<0.05).结论:铁超负荷与CHD病人冠状动脉狭窄密切相关,CHD病人应定期进行铁代谢指标检测.

Correlation between iron metabolism and coronary artery stenosis

Objective:To explore the correlation between iron metabolism and coronary artery stenosis in patients with coronary heart disease(CHD). Methods:Ninety-four CHD patients and 94 non-CHD patients were divided into the observation group and control group,respectively. The serum ferritin( SF) level and total iron binding capacity( TIBC) and ratio of SF/TIBC between two groups were compared. Results:The SF level and ratio of SF/TIBC in observation group were significantly higher than those in control group,and the TIBC in observation group was significantly lower than that in control group(P<0. 01). The differences of the SF level,TIBC and ratio of SF/TIBC between mild stenosis group,moderate stenosis group and severe stenosis group were statistically significant(P<0. 01). The results of pairwise comparison showed that the SF level and ratio of SF/TIBC in severe stenosis group were higher than those in mild stenosis group and moderate stenosis group,the TIBC in severe stenosis group was lower than that in other two groups( P<0. 05 and P<0. 01). The ratio of SF/TIBC in moderate stenosis group was higher than that in mild stenosis group,and the TIBC in moderate stenosis group was significantly lower than that in mild stenosis group(P<0. 01). The Gensini score in CHD patients was significantly positive correlated with SF level and ratio of SF/TIBC(r=0. 419,r=0. 624,P<0. 05),and significantly negatively correlated with TIBC(r= -0. 347,P<0. 05). Conclusions:Iron overload is closely associated with coronary artery stenosis in CHD patients. The iron metabolism indexes should be regularly detected in CHD patients.