IMP3、RFP蛋白检测对子宫内膜癌的评价价值研究

目的 分析IMP3、RFP蛋白检测对子宫内膜癌的评价价值.方法 选取50例子宫内膜癌患者为观察组,30例单纯子宫内膜增生患者为对照组.比较两组患者IMP3及RFP的表达情况;分析不同病理类型、组织分化、手术-病理分期、淋巴结转移、雌激素受体(ER)及孕激素受体(PR)表达的子宫内膜癌患者IMP3及RFP的差异;比较IMP3、RFP的诊断效力.结果 观察组IMP3及RFP的阳性表达率分别为36.0％和50.0％,均高于对照组的6.7％和10.0％,差异有统计学意义(χ2=8.604、13.187,P﹤0.05).Ⅱ型子宫内膜癌患者IMP3及RFP的阳性表达率明显高于Ⅰ型子宫内膜癌患者,差异有统计学意义(P﹤0.05),存在淋巴结转移的子宫内膜癌患者IMP3及RFP阳性表达率高于无淋巴结转移者,差异有统计学意义(P﹤0.05);PR阴性子宫内膜癌患者IMP3的阳性表达率高于PR阳性者,差异有统计学意义(P﹤0.05).IMP3、RFP对子宫内膜癌均有较高的敏感度、特异度.结论 IMP3、RFP对子宫内膜癌诊断效力高,具有一定的评价价值.

Value of IMP3 and RFP protein detection in the evaluation of endometrial carcinoma

Objective To analyze the value of IMP3 and RFP protein in the evaluation of endometrial carcinoma. Method 50 patients with endometrial carcinoma were included as study group, and 30 patients with simple endometrial hyperplasia were enrolled as control group, the expression of IMP3 and RFP were compared between the two groups. The differences of IMP3 and RFP in endometrial carcinoma patients with different pathological types, histological differentia-tion, clinical stage, lymph node metastasis, ER and PR expression were analyzed. The diagnostic efficiency of IMP3 and RFP were compared. Result The positive expression of IMP3 and RFP in study group was 36.0％ and 50.0％, which were higher than those in the control group at 6.7％and 10.0％, respectively, and the difference was statistically signifi-cant (χ2=8.604, 13.187, P<0.05). Type II endometrial carcinoma patients had markedly higher positive expression of IMP3 and RFP than that of type I endometrial carcinoma subjects (P<0.05), besides, presence of lymph node metastasis was also associated with increased IMP3 and RFP expression as compared with those without, the difference was of statis-tically significance (P<0.05);the positive rate of IMP3 in patients with PR negative endometrial carcinoma was signifi-cantly higher than that in PR positive patients (P<0.05);both IMP3 and RFP were of high sensitivity and specificity in de-tecting endometrial cancer. Conclusion IMP3 and RFP are potentially practical in the diagnosis of endometrial carcinoma.