清热散结方对非小细胞肺癌化疗患者免疫功能的影响研究

目的 探讨清热散结方对非小细胞肺癌化疗患者免疫功能的影响.方法 回顾性分析98例非小细胞肺癌化疗患者的临床资料,按患者是否采用清热散结方进行治疗将其分为观察组(清热散结方治疗联合化疗)和对照组(单纯化疗),每组49例.统计和分析两组患者临床疗效、不良反应发生情况及外周血中T细胞亚群水平:CD3+T细胞、CD4+T细胞、CD8+T细胞、CD4+/CD8+T细胞比值及CD4+CD25+调节性T淋巴细胞比例变化.结果 治疗后,观察组与对照组的有效率和疾病控制率比较,差异无统计学意义(P﹥0.05).治疗后,观察组骨髓抑制、胃肠道反应的发生率均低于对照组,差异有统计学意义(P﹤0.05);脱发、周围神经毒性、肾功能损害的发生率均低于对照组,但差异无统计学意义(P﹥0.05).治疗后,观察组外周血中CD3+、CD4+、CD4+/CD8+水平均高于对照组,差异有统计学意义(P﹤0.05);观察组CD8+水平低于对照组,差异有统计学意义(P﹤0.05);观察组CD4+/CD25+水平低于对照组,但差异无统计学意义(P﹥0.05).结论 清热散结方对减轻非小细胞肺癌化疗患者骨髓抑制和胃肠道反应有积极作用,且对改善机体免疫功能有促进作用.

Effect of Qingre Sanjie decoction on the immune function in patients of non-small cell lung cancer treated with chemotherapy

Objective To discuss the effect of Qingre Sanjie decoction on the immune function of patients with non-small cell lung cancer (NSCLC) treated with chemotherapy. Method 98 cases of NSCLC patients treated in our hospital were retrospectively analyzed, depending on the treatment, these patients were stratified as study group (Qingre Sanjie de-coction combined with chemotherapy) or control group (simple chemotherapy). Statistical analysis was performed for the clinical efficacy, adverse reactions and peripheral blood T cell subsets, including the percentage of CD3+T cell, CD4+T cell, CD8+T cell, CD4+/CD8+T cell in peripheral lymphocytes, and the change of the ratio of regulatory T lymphocyte CD4+CD25+. Result After treatment, the response rate and disease control rate in study group was of no significant dif-ference as compared with that in control group (P>0.05). Lower incidence of bone marrow suppression and gastrointesti-nal reactions was observed in study group compared to control group, with significant difference observed (P<0.05);the incidence of alopecia, peripheral neurotoxicity, renal dysfunction were lower in study group than control group, but the difference was not statistically significant (P>0.05). The percentage of CD3+, CD4+and CD4+/CD8+in the study group were significantly higher than those in the control group after treatment (P<0.05);the level of CD8+in study group was significantly lower than that in the control group (P<0.05);while the level of CD4+/CD25+was lower in study group than in control group, with no significant difference noted (P>0.05). Conclusion Qingre Sanjie decoction beneficial in allevi-ating the myelosuppression and gastrointestinal reactions in NSCLC patients after chemotherapy, and may also improve the immune function.