类风湿关节炎、中医舌象与细胞凋亡

目的:了解类风湿关节炎与细胞凋亡的研究进展,以期发现相互之间的关系及其变化规律,探讨类风湿关节炎细胞凋亡特征。资料来源:应用计算机检索1995-01/2003-12Medline和国家科技图书文献中心外文库与类风湿关节炎及细胞凋亡相关的文章,检索词为“rheumatoidarthritis,apoptosis”,限定文章语种为英文。计算机检索1995-01/2003-12重庆维普中文科技期刊数据库、清华同方中文科技期刊数据库和中国生物医学文献光盘数据库关于类风湿性关节炎与细胞凋亡相关的文章,限定文章语种为中文,检索词为“类风湿关节炎,细胞凋亡,舌象”。资料选择:对资料进行初审,选取类风湿关节炎与细胞凋亡相关性研究的文献开始查找全文。纳入标准:①类风湿关节炎与细胞凋亡的实验研究。②类风湿关节炎与细胞凋亡的临床研究。③中医舌象与细胞凋亡的研究。排除标准:重复性研究。资料提炼:共收集到82篇关于类风湿关节炎与细胞凋亡研究的文章,13篇符合纳入标准。排除的69篇文章中,58篇为重复性研究,11篇为综述类文章。资料综合:13篇文献中有11篇文献是通过实验研究和临床研究,从关节滑膜、外周血检测中发现类风湿关节炎存在着细胞凋亡异常,提示类风湿关节炎的发病、药物和物理治疗的实质均与滑膜细胞凋亡有关。余2篇是其他疾病舌象的细胞凋亡研究,揭示舌象细胞凋亡与疾病的病理相关,目前未找到有关类风湿关节炎舌象与细胞凋亡的有关报道,说明中医舌象与细胞凋亡的相关性研究存在许多空白。结论:中西医结合治疗类风湿关节炎具有优越性,从文献资料显示目前治疗类风湿关节炎的方法,可能通过影响类风湿关节炎的细胞凋亡而发挥作用。中医证型与细胞凋亡的研究仅限于少数的一两个病种,而舌象为证的重要诊断部分,故类风湿关节炎证(或舌象)细胞凋亡的内在联系有待研究,以进一步揭示类风湿性关节炎证的本质、舌象形成的机制。

Rheumatoid arthritis, traditional Chinese tongue demonstration and apoptosis

OBJECTIVE: To comprehend the development of research on rheumatoid arthritis (RA) and apoptosis so as to find the interrelationship and changing rules, probe into the apoptotic characteristics of RA.DATA SOURCES: A computer-based search of Medline and foreign language books of National Science and Technology Library was performed for English literatures related to RA and apoptosis from January 1995 to December 2003 with the key words of "rheumatoid arthritis,apoptosis".Meanwhile, Chinese articles about RA, traditional Chinese tongue demonstration and apoptosis were searched in Chongqing Vip Database of Chinese Scientific and Technical Periodicals, Tsinghua Tongfang Database of Chinese Scientific and Technical Periodicals and Chinese CD Database of Literatures on Biomedicine with the key words of "rheumatoid arthritis,apoptosis, tongue demonstration".STUDY SELECTION: Data were selected in the first searching, literatures on correlation between RA and apoptosis were searched in full-text.Accepting criteria: ①Experimental researches about RA and apoptosis. ②Clinincal researchs about RA and apoptosis. ③Researches on traditional Chinese tongue demonstration and apoptosis. Excluded criteria: Repetitive studies.DATA EXTRACTION: A total of 82 researches about RA and apoptosis werecollected, 13 ones in which were in accordance with the accepting criteria. Of the 69 excluded articles, 58 ones were repetitive studies and 11 ones were reviews.DATA SYNTHESIS: Of 13 literatures, 11 ones were checked by experimental research and clinical research. It was found from the examinations of synovium of joint and peripheral blood (PB) that there were abnomal apoptoses in RA, which indicated that the invasion, nature of drug and physical therapy were in relation to the apoptosis of synovial cells. Rest 2articles were researches on apoptosis of tongue demonstration of other diseases, which indicated that the apoptosis of tongue demonstration related to the pathology of disease. By now, there were no reports about RA, tongue demonstration and apoptosis, which indicated that there were still some blank in research about the correlation between traditional Chinese tongue demonstration and apoptosis.CONCLUSION: There is superiority in the treatment of RA with combined treatment of traditional Chinese medicine and western medicine. It is demonstrated in the literatures that treatment against RA at present may be done by affecting the apoptosis of RA. Researches on type of syndromes of traditional Chinese medicine and apoptosis is limited to a minority of one or two diseases, and tongue demonstration are an important part in the diagnosis on symptoms, therefore, the interrelationship of RA (or tongue demonstration) apoptosis needs to be investigated, Therefore, the inner relationship between tongue demonstration of RA and apoptosis needs investigation so as to furtherly reveal the formation mechanism of tongue demonstration.