Resistance Pattern of Streptococcus pneumoniae in Children During a Four-Year Period in Greece |
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Authors: | I Paraskakis E Lebessi N J Legakis V Skandami D A Kafetzis |
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Institution: | (1) Microbiology Laboratory of P. and A. Kyriakou Children's Hospital, Thivon & Levadias Street, GR-115 27 Athens, Greece, GR;(2) Department of Microbiology, Medical School, University of Athens, GR-115 27 Athens, Greece, GR;(3) Second Department of Pediatrics, Medical School, University of Athens, GR-115 27 Athens, Greece, GR |
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Abstract: | The resistance pattern of 432 Streptococcus
pneumoniae strains isolated from children with various infections over a 4-year period (1992–1995) was determined. The rates of resistance
to penicillin, chloramphenicol, tetracycline, trimethoprim-sulfamethoxazole, erythromycin, clindamycin, cefotaxime, and vancomycin
were 10%, 2.8%, 4.6%, 4.9%, 4.4%, 2.5%, 0.9%, and 0%, respectively. All strains not susceptible to penicillin were intermediately
susceptible to penicillin-(MIC >0.06–≤1 μg/ml). Isolates not susceptible to penicillin were encountered significantly more
often in children with localized infections than in those with invasive disease; these isolates displayed significantly lower
susceptibility to non-β-lactam agents as compared with their penicillin-susceptible counterparts. |
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Keywords: | |
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