| 新活素联合小剂量速尿治疗急性心肌梗死合并心力衰竭疗效评价 |
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| 引用本文： | 葛振嵘,姜述斌,帕尔哈提·吐尔逊,李岚,李秀芬,马骏,毛拉提,徐风燕,张保俭,祖丽比娅·艾萨. 新活素联合小剂量速尿治疗急性心肌梗死合并心力衰竭疗效评价[J]. 中国现代应用药学, 2015, 32(1): 100-104 |
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| 作者姓名： | 葛振嵘 姜述斌 帕尔哈提·吐尔逊 李岚 李秀芬 马骏 毛拉提 徐风燕 张保俭 祖丽比娅·艾萨 |
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| 作者单位： | 新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000,新疆医科大学附属中医医院 CCU 新疆 乌鲁木齐市 830000 |
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| 摘 要： | 目的观察新活素(rh BNP)联合小剂量速尿治疗急性心肌梗死合并心力衰竭的疗效。方法 50例急性心肌梗死伴心力衰竭患者随机分为治疗组(24例)和对照组(26例),治疗组在对照组基础上加rh BNP(0.5 mg·支-1,1.5μg·kg-1负荷剂量静脉推注3~5 min,然后以0.01μg·min-1·kg-1的速度持续滴注72 h,对照组予40 mg·d-1速尿静脉注射、病因治疗、扩血管等对症治疗,观察2组患者治疗前后相关心功能指标、血清脑利钠肽(BNP)、超敏C反应蛋白(hs-CRP)浓度的变化。结果治疗前后2组患者左心室舒张末期内径(LVDd)变化差异无统计学意义,治疗组LVEF明显升高(P<0.05),2组血浆BNP、血清hs-CRP水平均有下降(P<0.05),且治疗组较对照组改善更优(P<0.05)。结论 rh BNP联合小剂量速尿疗效明显优于速尿一般治疗,能有效改善急性心肌梗死合并心力衰竭患者症状,减少利尿剂抵抗。
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| 关 键 词： | 新活素 速尿 急性心肌梗死 心力衰竭 利尿剂抵抗 |
| 收稿时间： | 2014-02-03 |
| 修稿时间： | 2014-12-02 |
Evaluation of Recombinant Human Brain Natriuretic Peptide Combined with Low Dose Furosemide in the Acute Myocardial Infarction Complicating Heart Failure Therapy |
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| GE Zhen-rong,Jiang Shu-bin,Paerhati.tuerxu,Li Lan,Li Xiu-Feng,Ma Jun,Mao La-ti,Xu Feng-yan and Zhang Bao-jian. Evaluation of Recombinant Human Brain Natriuretic Peptide Combined with Low Dose Furosemide in the Acute Myocardial Infarction Complicating Heart Failure Therapy[J]. The Chinese Journal of Modern Applied Pharmacy, 2015, 32(1): 100-104 |
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| Authors: | GE Zhen-rong Jiang Shu-bin Paerhati.tuerxu Li Lan Li Xiu-Feng Ma Jun Mao La-ti Xu Feng-yan Zhang Bao-jian |
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| Affiliation: | Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University,Xinjiang Automonous Region Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University |
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| Abstract: | |
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| Keywords: | recombinant human brain natriuretic peptide combined with furosemide Acute myocardial infarction Heart failure Diuretic resistance |
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