Isolation and structure elucidation of new antibiotics related to angolamycin. |
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| Authors: | J Kádár-Pauncz B Podányi G Horváth |
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| Affiliation: | Institute for Drug Research, Budapest, Hungary. |
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| Abstract: | Angolamycin (1) and two novel analogues (2 and 3) were isolated from the culture broth of a Streptomyces strain. NMR and MS analysis proved that 2 is the 18-dihydro-, while 3 is the 18-deoxo-18-dihydro derivative of angolamycin. Full experimental assignment of the 1H and the 13C NMR spectra of these compounds was obtained from 1D and 2D chemical shift correlation measurements. Compounds 2 and 3 are less potent antibiotics than angolamycin. |
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