鼻咽癌患者微波热疗联合放疗前后T细胞亚群的变化及预后价值 |
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摘 要: |
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关 键 词: | 鼻咽癌 微波热疗联合放疗 T细胞亚群 |
Prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma] |
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Authors: | Yu-rong Qiu Lei Zheng Chun-li Yang Dong Wei De-hua Sun |
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Institution: | Department of Clinical Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. OYR@fimmu.com |
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Abstract: | OBJECTIVE: To assess the prognostic value of changes of peripheral blood T cell subsets after thermoradiotherapy for nasopharyngeal carcinoma (NPC). METHODS: Peripheral blood T cell subsets in 20 normal subjects (control group), 30 NPC patients undergoing thermoradiotherapy, and 20 NPC patients undergoing radiotherapy were detected by flow cytometry. RESULTS: The percentages of CD3+CD4+ and CD8+CD28+ cells were decreased and the percentages of CD3+CD8+ and CD8+CD28- cells increased as compared with the measurements in normal persons. One month after thermoradiotherapy, the percentages of CD3+CD4+ and CD8+CD28+ cells further decreased and the percentages of CD3+CD8+ and CD8+CD28- cells further increased, which continued to worsen 3 months after the treatment and appeared to be related to the survival of the patients. CONCLUSION: T cell subsets of NPC patients are abnormal and their immune functions depressed in NPC patients within a long period after thermoradiotherapy. CD8+CD28+ and CD8+CD28- T cell subsets can be significant for prognostic assessment in these patients after thermoradiotherapy. |
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