小剂量多巴酚丁胺负荷超声心动图对二尖瓣反流左室舒张功能的研究

探讨超声心动图评价二尖瓣反流左室舒张功能的可靠性方法。方法应用小剂量多巴酚丁胺负荷超声心动图（ＬＤＤＳＥ）对５０例二尖瓣反流（ＭＲ）患者进行了研究，其中包括２３例二尖瓣病变患者（Ａ组）和２７例扩张型或缺血性心肌病患者（Ｂ组）。结果Ａ组左室压力最大下降速率（－ｄｐ／ｄｔｍａｘ）和舒张期最大充盈速率（ＰＦＲ）显著高于Ｂ组，左室心肌松驰时间常数（Ｔ）显著短于Ｂ组的测值（Ｐ均〈０．００１）；给于多酚丁胺５

Study of left ventricular diastolic function in patients with mitral regurgitation by low-dose dobutamine stress echocardiography

Objective To study the reliable methods of assessing the left ventricular diastolic funtion in patients with chronic mitral regurgitation(MR).Methods Low-dose dobutamine stress echocardiography (LDDSE)were performed in 50 cases with MR,which included 23 cases with mitral valve diseases(grouD A)and 27 c&ses with dilated or i~hemic cardiomyopathy(group B).Results①There were higher negative maximal first derivation of left ventricular pressure(一dp/dtm),peak filling rate(PFR)and lower time constant of left ventricular isovolumetric relaxation(T)in group A than those in group B;②Dobutamine significantiv increased-dp/dtrnmax in both groups;⑧In group B dobutamine in induced an increase in PFR,early diastolic filling volume index(EDFVI),and the ratio of early tO late filling volume(EDFV/LDFV),and a decrease in T and E wave velocity and E/A ratio,peak reversal velocity at atrial contraction(Ar)in pulmonary venOus flow was also reduced (P<0.05).Conclusions Left ventricular relaxation and distensibility are impaired in dilated or ischemic cardiomyopathy with MR and the impaired left ventricle diastolic function may be improved bv dobutarnine.