Functional nuclear suppressor of mitochondrialoxi2 mutations in yeast |
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Authors: | Anna Kruszewska Barbara Szcześniak |
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Affiliation: | (1) Institute of Biochemistry and Biophysics Polish Academy of Sciences, 36 Rakowiecka Street, P-02532 Warsaw, Poland |
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Abstract: | Summary A semidominant nuclear suppressor, callednam6, ofoxi2-V276 mitochondrial mutation has been isolated and characterized. The nuclear character ofnam6 was proved by its retention inrho° strains, lack of mitotic segregation in diploids and meiotic 2:2 segregation in tetrads. The specificity ofnam6 was tested on 315mit– mutations of four mitochondrial genes (oxi1, oxi2, oxi3, andcob-box). It suppresses clearly only three mutations in theoxi2 gene, restoring partially or completely cytochrome aa3 formation. The results suggest a functional character of the suppression. |
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Keywords: | Yeast Mitochondria oxi2 mutations Functional suppressors |
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