Role of the specific determinant of group A streptococcus polysaccharide in inhibition of T-suppressor activity

Group A streptococcus polysaccharide is found to inhibit the activity of ConA-stimulated T suppressors. A-variant streptococcus polysaccharide, representing an L-rhamnose homopolymer which is identical to the rhamnose carcass of group A streptococcus polysaccharide, does not possess such an effect. The effect of group A streptococcus polysaccharide on the activity of T suppressors is considered to be associated with its determinant including N-acetylglucosamine as an obligatory component. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 201–203, February, 1995 Presented by S. V. Prozorovskii, Member of the Russian Academy of Medical Sciences