傣痛消对急性高尿酸血症小鼠血尿酸、血尿素氮的影响

目的:观察傣痛消对高尿酸血症小鼠血清尿酸(UA)、尿素氮(BUN)的影响。方法:通过酵母膏灌胃复制高尿酸血症动物模型,以"傣痛消"、别嘌呤醇干预,检测血清尿酸(UA)、尿素氮(BUN)的水平。结果:傣痛消高、中、低剂量组、别嘌醇组能显著降低小鼠血UA水平均显著低;"傣痛消"中、低剂量组、别嘌醇能明显降低小鼠血BUN浓度。结论:傣痛消对高尿酸血症小鼠具有良好的保护作用。

Effect of Daitongxiao on Blood Uric Acid and Blood Urea Nitrogen of Mice with Acute Hyperuricemia

Objective ： To investigate the effect of Daitongxiao on blood uric acid and blood urea nitrogen of mice with acute hy- peruricemia. Methods：The mice were divided into model, allopurinol （positive control,40 mg/kg） ,low- , mid-, and high- dose （260 mg/kg,780 mg/kg and 2340 mg/kg） DTX groups. Except the model group, mice in other groups were administered yeast （3000 mg/kg） once a day for 7 d. Positive control group were administered allopurinol （40 mg/kg） once a day for 4 d since the 7th day. Other low- ,mid- ,and high- dose DTX groups were administered since the 4th day for 4 d. The blood uric acid and blood urea nitrogen were determined after the last administration. Results ： Compared with the model group, DTX at mid - and high -dose could obviously decrease the blood uric acid level in mice （P 〈 0.01 ）. So could allopurinol （P 〈 0.0l ）. DTX at low - and mid -dose could obviously decrease the blood urea nitrogen level in mice （P 〈 0.01 ）. Conclusion：DTX could inhibit the in- crease of blood uric acid and blood urea nitrogen in mice with acute hyperuricemia.