| PHA对人扁桃体T淋巴细胞亚群变化及活化抗原表达的效应 |
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| 引用本文： | 林巧爱,陈英玉.PHA对人扁桃体T淋巴细胞亚群变化及活化抗原表达的效应[J].现代免疫学,1993,13(2):69-71. |
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| 作者姓名： | 林巧爱 陈英玉 |
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| 作者单位： | 温州医学院微生物和免疫学教研室，北京医科大学基础医学院免疫学教研室，北京医科大学基础医学院免疫学教研室，北京医科大学基础医学院免疫学教研室，北京医科大学基础医学院免疫学教研室 北京 100083，北京 100083，北京 100083，北京 100083 |
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| 摘 要： | 应用FITC和PE双色荧光试剂并经流式细胞计分析了人扁桃腺T淋巴细胞亚群组成,以及用PHA刺激后T淋巴细胞亚群的变化和活化抗原的表达情况。结果表明:1)人扁桃体T淋巴细胞以CD4~+细胞占优势,CD4~+与CD8~+细胞比值约为5.32±0.55;2),经PHA刺激培养72小时,CD4~+CD8~+细胞明显增加;3)经PHA刺激培养后,IL-2受体(CD25)和HLA-DR抗原表达增加。本实验结果为深入研究人扁桃体T淋巴细胞的表型变化提供了客观指标,对进一步探讨其在免疫系统中的作用具有一定的意义。
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| 关 键 词： | T淋巴细胞亚群 扁桃体 CD抗原 HLA-DR抗原 |
CHANGES IN T CELL SUBSETS AND EXPRESSION OFACTIVATION ANTIGENS ON HUMAN TONSILLAR TLYMPHOCYTES AFTER STIMULATION BYPHYTOHEMAGGLUTININ |
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| Lin Qaoai Chen Yingyu Ma Shujun Liu Bai Long Zhenzhou.CHANGES IN T CELL SUBSETS AND EXPRESSION OFACTIVATION ANTIGENS ON HUMAN TONSILLAR TLYMPHOCYTES AFTER STIMULATION BYPHYTOHEMAGGLUTININ[J].Current Immunology,1993,13(2):69-71. |
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| Authors: | Lin Qaoai Chen Yingyu Ma Shujun Liu Bai Long Zhenzhou |
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| Institution: | Lin Qaoai Chen Yingyu Ma Shujun Liu Bai Long Zhenzhou Department of Immunology,Beijing Medical University,Beijing |
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| Abstract: | The changes in percentages of human tonsillar T cell subsets and the expression of activation antigens on them after stimulation by PHA were studied with FACS 440 flow-cytometer. Originally the CD4+/CD8+ ratio was 5.32 ± 0.55. After 72 hours of culture with PHA, CD4+ CD8+ cells were markely increased. CD4+ cells were relatively decreased with a stable CD8+ cell population. Most of CD4+ cells expressed CD25 and HLA-DR antigens. CD8+ cells expressed them to a lesser degree. |
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| Keywords: | T cell subsets tonsil CD antigen HLA-DR antigen |
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