脑卒中后抑郁相关因素与患者预后分析研究

目的探讨脑卒中后抑郁的相关因素及患者预后分析。方法选择2008年2月～2011年2月本院住院治疗的280例脑卒中患者，采用抑郁自评量表、汉密尔顿抑郁量表对患者进行评估。280例患者中确诊为卒中后抑郁者62例，将32例接受早期干预治疗的卒中后抑郁者为观察组，30例未接受早期干预者为对照组。对可能引起脑中后抑郁的相关因素进行分析，并采用改良Barthel指数评估患者日常生活能力（ADL），采用FMA运动功能评定肢体运动功能。结果统计学分析显示文化程度、家庭关系、病变部位、偏瘫严重程度与患者脑卒中后抑郁显著相关（P〈0．05），而性别、年龄及卒中次数无明显相关性（P〉0．05）；治疗后1、3及6个月进行评估，结果显示观察组MBI评分及FMA评分显著优于对照组（P〈0．05）。结论文化程度、家庭关系、病变部位、偏瘫严重程度是脑卒中患者发现卒中后抑郁的危险因素，早期干预的脑卒中后抑郁患者预后显著优于未干预者，临床治疗中应给予早期干预措施，以促进患者康复．改善预后。

Research on related factors of post-stroke depression and their relationship with prognosis

Objective To explore the related factors of post-stroke depression and their relationship with prognosis.Methods 280 cases with acute stroke from February 2008 to February 2011 were selected as research subjects.SDS and hamilton depression scale were performed to evaluate depressive state.62 patients were diagnosed as post-stroke depression among 280 cases.Post-stroke depression patients were divided into experience group and control group.32 cases of experience group were given early treatment and 30 patients of control group didn′t receive early treatment.Related factors linked to post-stroke depression were analyzed.MBI and FMA were used to evaluate ADL and extremity motor function pre and post treatment.Results Culture degree,family relationship,lesion site,the hemiplegic degree had a close relationship with the onset of post-stroke depression(P < 0.05);No evidence showed significant correlation among the age,gender and stroke frequency with disease(P > 0.05);MBI scores and FMA scores in experience group were much better than that in control group on 1,3 and 6 months of post-treatment(P < 0.05).Conclusion Culture degree,family relationship,lesion site,the hemiplegic degree are the risk factors for post-stroke depression.The patients who receive early treatment have better prognosis.Early treatment should be performed in order to promote the recovery and improve the prognosis of patients.