塞来昔布联合盐酸氨基葡萄糖治疗膝骨性关节炎

目的探讨塞来昔布联合盐酸氨基葡萄糖治疗膝骨性关节炎的临床效果和安全性。方法选择我院2008～2011年收治的膝骨性关节炎患者64例,随机分为两组,每组各32例,观察组给予塞来昔布联合盐酸氨基葡萄糖治疗,对照组仅给予塞来昔布治疗,分别于治疗前、治疗后应用Lequesne评分标准指数评价关节功能改善情况,并对两组患者不良反应情况进行比较。结果两组患者经过治疗后Lequesne均显著下降,但观察组各项指标下降幅度显著好于对照组（P〈0.05）,且观察组在治疗6和12个月后关节软骨磨损阳性征象数目减少程度显著好于对照组（P〈0.05）。两组患者治疗期间均有不良反应情况发生,但发生率无显著性差别（P〉0.05）。结论塞来昔布联合盐酸氨基葡萄糖治疗膝骨性关节炎临床效果显著,可在控制症状、改善关节功能同时,长期维持疗效,并具有良好的胃肠道耐受性。

Evaluation of Celecoxib combined with Glucosamine Hydrochloride in treating patients with knee osteoarthrifis

Objective To investigate the clinical effect and safety of Celecoxib combined with Glucosamine Hydrochloride in treating patients with knee osteoarthrifis.Methods 64 patients with knee osteoarthrifis were selected and divided into two groups for each 32,patients in observation group were given Celecoxib combined with glucosamine hydrochloride,other patients in control group were given Celecoxib,the score index of Lequesne and bad reaction were compared.Results The scores index of all the patients were all decreased,however,the improvement of observation group was significantly better than that of control group(P < 0.05),and the number of articular cartilage wear positive signs of observation group were also better than control group after 6 and 12 months(P < 0.05),there was no difference between two groups in bad reaction(P > 0.05).Conclusion The method of Celecoxib combined with glucosamine hydrochloride has a good effect,and also has a virtue of safety long efficiency,which is deserve to be used in clinic.