| 亚甲基四氢叶酸还原酶基因多态性与2型糖尿病相关性研究 |
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| 引用本文： | 梅庆步,陈萍,郑立红. 亚甲基四氢叶酸还原酶基因多态性与2型糖尿病相关性研究[J]. 中国医药导报, 2012, 9(22): 162-163 |
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| 作者姓名： | 梅庆步 陈萍 郑立红 |
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| 作者单位： | 齐齐哈尔医学院生物遗传教研室,黑龙江齐齐哈尔,161000 |
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| 摘 要： | 目的研究亚甲基四氢叶酸还原酶（MTHFR）基因多态性与2型糖尿病（T2DM）的关系。方法应用PCR-RFLP方法检测91例2型糖尿病患者及124例健康对照者MTHFR基因C677T多态位点基因型，并进行统计分析。结果2型糖尿病组MTHFR基因1Tr纯合基因型频率为25．27％，CT杂合基因型频率为56．04％，T等位基因频率为53．29％。与健康对照组比较（29．84％、56．45％、58．06％），差异均无统计学意义（P〉0．05）。结论MTHFR基因677位点多态性与2型糖尿病无相关关系。
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| 关 键 词： | 2型糖尿病 亚甲基四氢叶酸还原酶 基因多态性 |
Correlation study between gene polymorphism of methylene tetrahydrofolate reductase and type 2 diabetes |
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| MEI Qingbu , CHEN Ping , ZHENG Lihong. Correlation study between gene polymorphism of methylene tetrahydrofolate reductase and type 2 diabetes[J]. China Medical Herald, 2012, 9(22): 162-163 |
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| Authors: | MEI Qingbu CHEN Ping ZHENG Lihong |
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| Affiliation: | Teaching and Research Section of Biological Genetic,Qiqihar Medical School,Heilongjiang Province,Qiqihar 161000,China |
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| Abstract: | Objective To study the correlation between gene polymorphism of methylene tetrahydrofolate reductase(MTHFR) and type 2 diabetes(T2DM).Methods C677T polymorphism genotype of MTHFR in 91 cases of T2DM patients and 124 healthy controls were detected with PCR-RFLP method and were subjected to statistical analysis.Results TT homozygous genotype frequencies of the MTHFR gene in T2DM group was 25.27%,CT heterozygous genotype frequency was 56.04% and T allele frequency were 53.29% and the distribution were not significantly different form those in the healthy control group(29.84%,56.45%,58.06% respectively)(P > 0.05).Conclusion 677 gene polymorphism of MTHFR is not related to T2DM. |
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| Keywords: | Type 2 diabetes Methylene tetrahydrofolate reductase Gene polymorphism |
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