难治性抑郁症和首发抑郁症听觉P50与认知功能的相关研究

目的探讨难治性抑郁症（TRD）和首发抑郁症（FED）患者听觉诱发电位P50和认知功能的相关性及其可能的神经生理机制。方法应用美国NicoletBravo脑电生理仪，对33例TRD、37例FED和35名健康对照者（HC）进行P50和认知功能检测，并对两者进行相关分析。结果①TRD患者的S2-P50波幅以及S2/S1，S1-S2和100（1-S2／S1）三种表达式与FED、HC组存在显著性差异（P〈0．05或P〈0．01）；②TRD患者的总智商、操作智商、长时记忆和短时记忆与FED、HC组存在显著性差异（P〈0．05或P〈0．01）；③TRD患者的P50异常指标与其短时记忆中的图片、再生和触觉功能损害显著相关（P〈0．05或P〈0．01）。结论TRD患者比FED患者存在更为显著的感觉门P50异常和认知功能损害，其P50异常与患者的短时记忆损害存在显著的相关性。

Correlational study between auditory sense P50 and cognitive function in treatment-resistant depression and first episode depression patients

Objective To explore the relationship between auditory evoked potential P50 and cognitive function and their possible neurophysiology mechanism in treatment-resistant depression(TRD) and first episode depression(FED) paitents.Methods American Nicolet Bravo instrument was used.P50 and cognitive function were tested and their correlation was analyzed in 33 TRD,37 FED patients and 35 healthy controls(HC).Results ①Compared with FED and HC,significant differences were showed in S2-P50 amplitudes,S2/S1,S1-S2 and 100(1-S2/S1) in TRD group(P < 0.05 or P < 0.01).②Compared with FED and HC,significant differences were showed in FIQ,PIQ,long and short term memory in TRD group(P < 0.05 or P < 0.01).③ Significant correlation were found between abnormal P50 indexes and picture,regeneration and tactus of short term memory in TRD group(P < 0.05 or P < 0.01).Conclusion TRD patients show more severe sensory gating P50 abnormality and cognitive function impairments than FED patients,and their P50 changes show significant correlation with short term memory impairment.