前列腺素E1联合贝那普利治疗早期特发性膜性肾病疗效观察

目的探讨前列腺素E1（PGE1）联合贝那普利对早期特发性膜性肾病的临床疗效。方法选择早期特发性膜性肾病患者52例,采用前瞻、随机、对照研究,分为对照组、PGE1组、贝那普利组、PGE1＋贝那普利组。对照组仅给予限制蛋白饮食,血脂升高者给予降脂等一般治疗;PGE1组在对照组基础上给予PGE1 100μg加5%葡萄糖100 mL静滴,每日1次,共用4周;贝那普利组在对照组地基础上给予贝那普利10 mg/d,如无副作用及低血压,增加剂量至20 mg/d;PGE1＋贝那普利组在PGE1组的基础上合用贝那普利10～20 mg/d,每日1次,共用4周。结果与治疗前比较,除对照组外,PGE1组、贝那普利组与PGE1＋贝那普利组24 h尿白蛋白量均有下降（P〈0.01）;与其他组比较,PGE1＋贝那普利组作用更显著（P〈0.05）。结论 PGE1联合贝那普利对早期特发性膜性肾病有较好的治疗效果。

Therapeutic efficacy of prostaglandin E1 combined with Benazepril in the treatment of early idiopathic membranous nephropathy

Objective To investigate the therapeutic efficacy of prostaglandin E 1(PGE 1) combined with Benazepril in the treatment of early idiopathic membranous nephropathy.Methods 52 cases of early-stage idiopathic membranous nephropathy patients were enrolled in a prospective randomized controlled study.Patients were assigned to control group,PGE 1 group,Benazepril group and PGE 1 combined with Benazepril group.The control group only received restricted protein diet and patients with elevated blood lipids were given general treatment of lipid-lowering;In addition to that,PGE 1 group were given intravenous infusion of 20 μg PGE 1 in 100 mL 5% glucose once a day,for 4 weeks;in addition to treatment given in the control group,patients in the Benazepril group were given Benazepril 10 mg/d and the dose was raised to 20 mg/d in the absence of side effects and low blood pressure;patients in the PGE 1 combined with Benazepril group were given Benazepril 10-20 mg/d for 4 weeks in addition to treatment given in the PGE 1 group.Results Except for control group,after treatment 24 h urinary albumin volume decreased in PGE 1 group,Benazepril group and PGE 1 combined with Benalapril group(P<0.01);compared with other groups,PGE 1 combined with Benazepril group showed more significant effect(P<0.05).Conclusion PGE 1 combined with Benazepril shows promising therapeutic efficacy in the treatment of early idiopathic membranous nephropathy.