鳞状上皮细胞癌抗原和HPV-DNA联合检测对宫颈癌诊断的临床意义

目的研究鳞状上皮细胞癌抗原（SCC-AG）和HPV基因分型联合检测对宫颈癌诊断的临床意义。方法对到本院就诊的宫颈病变患者采取SCC-AG及HPV基因分型检测,将单纯SCC-AG检测的阳性率及HPV基因分型检测阳性率分别与联合检测结果进行对比。结果 SCC-AG检测阳性率为11.21%,准确率为64.62%;HPV-DNA检测阳性率为14.31%,准确率为73.49%;联合检测阳性率为10.00%,准确率为94.83%。单纯HPV-DNA检测阳性率与联合检测阳性率相比,差异有统计学意义（P〈0.05）。结论 SCC-AG和HPV基因分型联合检测可明显提高宫颈癌的检出率,避免漏诊与误诊,对于宫颈癌的临床诊断具有重要的临床指导意义。

The clinical significance of squamous cell carcinoma antigen and HPV-DNA joint detection in diagnosis of cervical cancer

Objective To study the clinical significance of squamous cell carcinoma antigen(SCC-AG) and HPV genotyping joint detection in diagnosis of cervical cancer.Methods Patients with cervical lesions treated in our hospital were adopted squamous cell carcinoma antigen(SCC-AG) and HPV genotyping detection.The positive rate of the simply detection of SCC-AG and HPV genotyping were compared with the joint test results.Results The positive rate of SCC-AG detection was 11.21%,the accuracy rate was 64.62%.The positive rate of HPV-DNA detection was 14.31%,the accuracy rate was 73.49%%.The positive rate of joint detection was 10.00%,the accuracy rate was 94.83%.The positive rate between the simply HPV-DNA detection and the joint detection was compared,the difference was statistically significant(P < 0.05).Conclusion SCC-AG and HPV-DNA joint detection can significantly improve the detection rate of cervical cancer,avoid missed diagnosis and misdiagnosis,it has important clinical significance for the clinical diagnosis of cervical cancer.