亚低温辅助治疗对急性重型颅脑损伤患者外周血神经元特异性烯醇化酶、一氧化氮和C反应蛋白水平的影响

目的探讨亚低温治疗对急性重型颅脑损伤患者外周血神经元特异性烯醇化酶（NSE）、一氧化氮（NO）和C反应蛋白（CRP）水平的影响。方法将90例急性重型颅脑损伤患者随机分为对照组（n=45）和观察组（n=45）。两组均给予常规治疗,观察组联合亚低温辅助治疗。观察治疗前后两组患者的外周血神经元特异性烯醇化酶（neuronspecific enolase,NSE）、一氧化氮（nitric oxide,NO）和C反应蛋白（C-reactive protein,CRP）水平变化。结果观察组预后良好率和病死率分别为46.67%（21/45）和11.11%（5/45）,明显优于对照组的28.89%（13/45）和24.44%（11/45）（P〈0.05）。治疗后第3、5天和复温后（第7天）观察组NSE、NO和CRP水平均明显低于对照组（P〈0.05）。结论亚低温辅助治疗急性重型颅脑损伤的疗效显著,可有效降低NSE、NO和CRP的水平,减轻脑组织的继发性损伤,降低病死率,改善预后。

The influence of mild hypothermia auxiliary treatment on blood neurons specific enolase,nitric oxide and C-reactive protein in patient with acute severe brain injury

Objective To study the influence of mild hypothermia auxiliary treatment on blood neurons specific enolase(NSE),nitric oxide(NO) and C-reactive protein(CRP) in patient with acute severe brain injury.Methods 90 cases of patients with acute severe brain injury were randomly divided into the control group(n = 45) and the observation group(n = 45).The two groups were all given conventional therapy,the observation group were combined with mild hypothermia auxiliary treatment.The change of blood NSE,NO and CRP before and after treatment in the two group were observed.Results The recovery rate and mortality in the observation group were 46.67%(21/45) and 11.11%(5/45) respectively,which were much better than 28.89%(13/45) and 24.44%(11/45) in the control group(P < 0.05).NSE,NO and CRP levels of the observation group were significantly lower than those of the control group at 3,5 days and rewarming after treatment(P < 0.05).Conclusion The effect of mild hypothermia auxiliary treatment on patient with acute severe brain injury is distinct,which can effectively reduce NSE,NO and CRP levels,reduce the secondary injury of brain and mortality,improve the prognosis.