老年与青年胃食管反流病患者临床特征多中心对照研究

目的探讨胃食管反流病患者人群不同年龄的临床特征。方法回顾性分析我院2009年6月-2010年4月收治的经胃镜检查确诊为反流性食管炎（RE）的患者100例的临床资料，根据年龄不同分为两组，其中，年龄≥65岁50例为老年组，年龄〈65岁50例为中青年组；观察食管炎分级、分类标准p3，以及食管裂孔疝（HH）发生情况，并采用反流性疾病问卷、生活质量问卷等分析不同年龄组患者的临床特征。结果老年组食管症状积分（除反酸烧心）为（9．120±1．048）分，明显高于中青年组的（7．970±3．797）分（P〈0．05）；老年组食管外症状积分为（6．480±2．063）分，亦明显高于中青年组的（2．730±1．276）分（P〈0．05）；老年组食管外症状发生率（64．8％）较中青年组（36.4％）高（P〈0．05）；老年组除总体健康、社会职能、活力、精神健康和生理功能积分差异无统计学意义外，其余各维度积分，老年组均高于中青年组（P〈0．05）。结论老年GERD患者典型反流症状（反食、烧心）较少见，易发生重度食管炎，但老年GERD患者生活质量无明显下降。

Young and elderly patients with gastroesophageal reflux disease clinical multicenter controlled study

Objective To investigate the elderly and young gastroesophageal reflux disease(GERD) in patients with clinical features for clinical diagnosis and treatment to help.Methods The clinical data of 100 cases who were diagnosed as RE by gastroscope in our hospital from June 2009 to April 2010 were analyzed retrospectively.Patients were divided into age group(age ≥ 65 years) 50 cases and middle-aged group(age < 65 years) 50 cases according to different age,the degree of RE,classification standard p3,hiatal hernia(HH),and the clinical features were analyzed by reflux diagnostic questionnare(RDQ) scale and the quality of life(QL-Index) scale.Results The esophageal symptoms integral of age group was(9.120±4.048) points,higher than the(7.970±3.797) points of middle-aged group(P < 0.05).The esophageal external symptoms integral of age group was(6.480±2.063) points,also higher than the(2.730±1.276) points of middle-aged group(P < 0.05).The rate of esophageal external symptoms of age group(64.8%) was higher than the middle-aged group(36.4%)(P < 0.05),age group except general health,social function,activity,mental health and physical function score was no significant difference,the rest of the dimensions of the points in the elderly group were higher than the young group(P < 0.05).Conclusion Elderly patients with GERD typical reflux symptoms(anti-food,heartburn) is less common,high incidence of severe esophagitis,but the quality of life of elderly patients with GERD had no significant decline.