绝经前卵巢上皮性癌预后因素分析

目的探讨影响绝经前卵巢上皮性癌患者生存预后的相关因素。方法回顾性分析2000年1月～2007年1月共163例绝经前卵巢上皮性癌患者临床资料,评估预后因素。随访时间为5年,各分层因素间生存率比较采用χ2检验,寿命法计算生存率,Kaplan-meier法分析变量,Log-rank法检验生存差异,COX多因素模型进行多因素分析。结果绝经前卵巢上皮性癌患者2年生存率为79.75%,5年生存率为46.01%。单因素逐步COX模型分析与分层因素间生存率比较结果显示：临床分期、病理类型、细胞学分级、残留灶大小、手术方式是影响预后的重要因素（P〈0.01）。逐步COX模型多因素分析显示：其细胞学分级、残留灶大小、手术方式是影响预后的独立因素（P〈0.01）。单因素Logistic回归分析显示：不同因素下各组间5年生存率存在差异（P〈0.01）。结论绝经前卵巢上皮性癌患者临床分期早,细胞分化好,术后残余病灶越小,预后越好,根据以上因素可预测绝经前卵巢上皮性癌患者生存概率。

Clinical analysis about prognostic factors of the ovarian epithelial cell in cancer premenstrual woman

Objective To investigate prognostic factors of the premenstrual woman with ovarian epithelial cell cancer.Methods From January 2000 to January 2007,the data on 163 cases of patients were collected,and the factors which affected prognosis were retrospectively analyzed.Based on five years of follow-up,the survival rate was compared between layer factors with chi-square test,life method was used in calculation of survival,Kaplan-meier,Log-rank and COX multi-factor mode analytic method was respectively adopted to analyze variables,survival differences and multi-factors analysis.Results The 2-year survival rate was 79.07%,with a 46.01% 5-year survival rate;the cytology grade,residual tumor size and the method of surgery were prognostic factors(P < 0.01) according to the Cox-model multifactor results;based on the COX model multi-factor analysis,cytology classification,residual focal size,the operation method were the independent factors affecting the prognosis(P < 0.01);A statistical significance was found about the 5-year survival rate between every group under a different layer factors by a single factor Logistic regression analysis(P < 0.01).Conclusion The research data shows earlier staging,higher cell differentiation,fewer residual focal size,more optimistic prognosis for the premenstrual epithelial ovarian carcinoma.