成纤维细胞生长因子受体2多态性与乳腺癌相关性研究

目的研究成纤维细胞生长因子受体2（FGFR2）基因单核苷酸多态性（SNP）与乳腺癌相关性。方法对280例乳腺癌患者及280例健康女性进行ASA—PCR检测，分析其三个位点（rs2912778、rs2981582、rs2981578）SNP与乳腺癌风险关系。结果三个位点（rs2912778、rs2981582、rs2981578）基因型分布在乳腺癌组和对照组中差异具有统计学意义（P〈0．05）；与病理资料进一步联系分析，除rs2912778在淋巴结转移方面野生型与变异型差异具有高度统计学意义（P〈0．01）之外，其余三个位点野生型与变异型相比差异均无统计学意义（均P〉0．05）。结论FGFR2基因三个位点单核苷酸多态性可能与乳腺癌的发生有关。

Relative research of FGFR2 Gene SNPs and breast neoplasm

Objective To investigate whether single nucleotide polymorphisms(SNP) of fibroblast growth receptor 2(FGFR2) are associated with breast cancer risk.Methods In the present study of 280 breast cancer patients and 280 cancer-free controls,we tested three FGFR2 polymorphisms(rs2981582,rs2981578A/G and rs2912778) the method of ASA-PCR.Results Differences were found in the genotypes between the breast neoplasm group and the control group of all loci(P < 0.05).Among three loci,except rs2912778(P < 0.01) in FGFR2 was related to lymph node metastasis,any difference between wild-type and variant-type in clinical pathological factors were not found(all P > 0.05).Conclusion The findings indicate that genetic variants in FGFR2 may contribute to breast cancer occurrence.