124例宫颈上皮内瘤样病变病例5年随访分析

目的探讨宫颈细胞学检查和人乳头状瘤病毒（HPV）检测在宫颈上皮内瘤变（CIN）的筛查及随访中的临床应用。方法回顾性分析我院2006年收治的124例CIN患者的临床资料,并采用液基细胞学技术（TCT）、HPV检测等进行5年随访。结果 124例患者中,TCT检查结果与病理结果的符合率为41.9%,Spearman秩相关结果显示,TBS分级与病理等级呈显著负相关（r=-0.22,P〈0.05）。高危型HPV（＋）占84.7%,其中,HPV16型占58.1%,HPV58型占17.2%,HPV52型占15.2%和HPV51型占9.5%。5年随访中均未见宫颈病变复发或升级。结论 TCT联合HPV检测可应用于CIN的筛查及随访。

Analysis of 5-year follow-up results in 124 cervical intraepithelial neoplasia patients

Objective To explore the clinical application value of thin prep cytologic test(TCT) and human papilloma virus(HPV) detection in the screening and follow-up for patients with cervical intraepithelial neoplasia(CIN).Methods The clinical data of 124 patients with CIN who were treated in our hospital in 2006 was retrospectively analyzed,and all the patients were followed up for 5 years by using TCT and HPV detection.Results Among 124 patients,the consistent rate of pathology diagnosis and TCT results was 41.9%.The results of Spearman rank showed there was a significant negative correlation between TBS classification and pathology rank(r =-0.22,P < 0.05).High risk HPV positive 84.7%,including HPV16 58.1%,HPV58 17.2%,HPV52 15.2% and HPV51 9.5%.There was no recurrence found in the 5-year follow-up.Conclusion TCT and HPV detection can be used in screening and follow-up of CIN patients.