c—Met、PTEN在甲状腺癌中的表达及其临床意义

目的研究c—Met、PTEN在甲状腺癌中的表达和临床价值。方法采用免疫组织化学SP法检测c—Met、PTEN在甲状腺癌、甲状腺腺瘤及正常甲状腺组织中的表达，并对其在不同病理类型、临床分期的甲状腺癌中的标记结果进行对照和相关性分析。结果c—Met、PTEN在72例甲状腺癌中的阳性率分别为63．9％和62．5％，与正常甲状腺、甲状腺腺瘤分别相比，差异有统计学意义（P〈0．05）。其在不同病理类型、临床分期、病理分级和区域淋巴结转移的甲状腺癌病例中的表达结果相比，差异有统计学意义（P〈0．05），而与肿瘤大小、瘤体有无侵出包膜、患者性别及年龄无关（P〉0．05）。c—Met与PTEN的表达均呈负相关（r=-0．340，P〈0．01）。结论c—Met、PTEN在甲状腺癌的衍变过程中可能扮演重要角色，二者联合标记可能作为评估甲状腺癌恶性度及预后的有效参考，并可能为其靶向治疗提供思路。

Expression of c-Met,PTEN in thyroid carcinoma and its clinical significance

Objective To explore the expression of c-Met and PTEN in thyroid carcinoma and its clinical value.Methods Expression of c-Met and PTEN in specimen of thyroid carcinoma(TC),thyroid adenomas and normal thyroid tissues was detected by SP method of immunohistochemistry(IHC).Then the marker results in those with different pathological category and clinical stages were compared,and correlation analysis was made.Results The positive rate of c-Met and PTEN in 72 TC specimen was 63.9% and 62.5%,compared with the normal thyroid tissues and thyroid adenomas respectively,there was a significant difference(P < 0.05).Also there were significant differences in sign results of different pathological types,the clinical and pathologic stages,classification and regional lymph node metastasis status(P < 0.05).Otherwise,there was no statistical difference among tumor size,inside/outside of diolame,patients′ gender and age(P > 0.05).C-Met with the PTEN gene’s expression was negatively(r =-0.340,P < 0.01).Conclusion c-Met and PTEN genes robably play an important role in the evolvement of TC.Joint marking these two genes may offer an effective reference for evaluation of malignant degree and prognosis of thyroid cancer and may even afford a mentality to the targeted therapy.