抗癫药物与心血管疾病危险因素

的发生率和死亡率，而 CVD 可诱发癫猝死。不同的抗癫药物对 CVD 危险因素的影癫与心血管疾病（cardiovascular disease，CVD）互为因果，癫可增加 CVD响各异，这些危险因素包括体质量、胰岛素抵抗、代谢综合征、血清尿酸水平、颈动脉内膜中层厚度和氧化应激标志物等。鉴于部分抗癫药物可能增加或降低 CVD 发生风险，因此在实施个体化的抗癫治疗时，对于有较高 CVD 发生风险的癫患者应选择合适的抗癫药物，同时合理使用可降低 CVD 发生风险的药物。

Antiepileptic drugs and risk factors of cardiovascular disease

There is a reciprocal causal relationship between epilepsy and cardiovascular disease (CVD), which means that epilepsy may increase the incidence rate and mortality of CVD, while the CVD may induce the sudden unexpected death in epilepsy. Different antiepileptic drugs have different effects on the risk factors of CVD including body weight, insulin resistance, metabolic syndrome, serum uric acid level, carotid artery intima-media thickness and markers of oxidative stress. In view of the fact that some antiepileptic drugs may increase or reduce the risk of occurrence of CVD, therefore, in individualized antiepileptic therapy, appropriate antiepileptic drugs should be selected for patients with high risk of CVD, meanwhile, the rational use of drugs which can reduce the risk of CVD is recommended.