经尿道膀胱肿瘤电切术后不同药物膀胱灌注化疗对50例浅表性膀胱癌患者疗效及生存预后的影响

目的：探讨经尿道膀胱肿瘤电切术后不同药物膀胱灌注化疗对浅表性膀胱癌患者的疗效及生存预后的影响。方法：回顾性分析我院收治的浅表性膀胱癌患者100例，所有患者均给予常规尿道电切切除术治疗，依据治疗方法分为对照组（术后给予40 mg丝裂霉素化疗治疗）和观察组（术后给予30 mg吡柔比星化疗治疗）各50例，采用ELISA检测血清血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGF）、基质金属蛋白酶-9（MMP-9）水平，随访3年，统计分析所有患者治疗前后VEGF、FGF、MMP-9水平、不良反应、复发和生存情况。结果：治疗后，观察组患者血清VEGF、FGF、MMP-9水平明显低于对照组（P＜0.05）；对照组和观察组患者不良反应发生率无显著性差异（P＞0.05）；观察组患者0.5、1、2、3年累积生存率明显高于对照组，前者复发率明显低于后者（P＜0.05）。结论：经尿道膀胱肿瘤电切术联合吡柔比星膀胱灌注化疗可有效减弱膀胱癌血管新生及癌细胞侵袭等恶性生物学行为，减少患者术后复发和改善生存预后，且无增加不良反应发生的风险。

Effects of bladder irrigation chemotherapy with different drugs on 50 patients with superifcial bladder cancer after transurethral resection of bladder tumor and their prognosis

Objective: To investigate the effects of bladder irrigation chemotherapy with different drugs after transurethral resection of bladder tumor on patients with superifcial bladder cancer and their prognosis. Methods:One hundred cases of patients with superficial bladder cancer in our hospital were retrospectively analyzed, and they were treated with conventional transurethral resection and divided into a control group (underwent chemotherapy with 40 mg of mitomycin after surgery) and an observation group (underwent chemotherapy with 30 mg of pirarubicin after surgery) with 50 cases each. The levels of serum vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and matrix metalloproteinase-9 (MMP-9) were determined by ELISA. All the patients were followed-up for 3 years. The levels of VEGF, FGF and MMP-9, the incidence of adverse reactions and recurrence and the survival condition before and after treatment were also analyzed. Results:After treatment, the levels of serum VEGF, FGF and MMP-9 were obviously lower in the observation group than in the control group (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no signiifcant differences (P>0.05). The cumulative survival rates in the 0.5, 1, 2 and 3 years after surgery were significantly higher while the recurrence rates were signiifcantly lower in the observation group than in the control group (P<0.05). Conclusion:Transurethral bladder tumor resection combined with intravesical irrigation chemotherapy with pirarubicin can effectively reduce the malignant biological behavior such as angiogenesis and cell invasion of bladder cancer and the postoperative recurrence and improve the prognosis, and not increase the risk of adverse reactions.