胶原酶溶解术治疗颈椎间盘突出症2769例临床分析

目的：回顾性总结胶原酶溶解术治疗颈椎间盘突出症的临床疗效及不良反应，探讨胶原酶溶解术治疗颈椎间盘突出症的临床实用价值。方法：收集2006年1月至2015年12月经颈椎MRI扫描证实为颈椎间盘突出症，接受胶原酶溶解术治疗，且资料完整的2769例患者进行疗效分析。结果：2769例中，疗效优1440例（52.0%）、良787例（28.4%）、可351例（12.7%）、差191例（6.9%）；优良率为80.4%，总有效率为93.1%。未发现明显不良反应。结论：胶原酶溶解术治疗颈椎间盘突出症安全、有效，其作用机制有待进一步研究。

Clinical analysis of collagenase chemonucleolysis in the treatment of 2 769 cases of cervical disc herniation

Objective:The clinical efifcacy and adverse reactions of collagenase chemonucleolysis in the treatment of cervical disc herniation were retrospectively summarized and its clinical value was also discussed. Methods:Twenty-seven hundreds and sixty-nine cases of patients with cervical disc herniation undergoing collagenase chemonucleolysis with complete data were collected and the efifcacy of treatment was analyzed. Results:There were 1 440 cases (52.0%) with excellent efifcacy, 787 cases (28.4%) with good efifcacy, 351 cases (12.7%) with medium efifcacy and 191 cases (6.9%) with bad efifcacy among 2 769 cases, in which the excellent rate and the total effective rate accounted for 80.4%and 93.1%. None of signiifcant adverse reactions was found. Conclusion:Collagenase chemonucleolysis is safe and effective in the treatment of cervical disc herniation, however its mechanism of action remains to be further studied.