| Y染色体异常对男性生育力的影响 |
| |
| 引用本文： | 高久春,祁聪阳,郑贤红,李哲,刘睿智,张志宏,邢沈阳. Y染色体异常对男性生育力的影响[J]. 中国妇幼保健, 2007, 22(35): 5011-5013 |
| |
| 作者姓名： | 高久春 祁聪阳 郑贤红 李哲 刘睿智 张志宏 邢沈阳 |
| |
| 作者单位： | 1. 吉林大学白求恩医学院细胞生物学教研室·吉林省生殖医学研究所,长春,130021
2. 吉林大学畜牧兽医学院 |
| |
| 摘 要： | 目的:探讨Y染色体异常对男性生育力的影响。方法:对1656例遗传咨询者进行外周血淋巴细胞常规培养,制备染色体G显带标本,镜下核型分析。结果:1656例遗传咨询者中,检出Y染色体异常30例,异常率为1.81%(30/1656)。其中Y染色体数目异常5例,占异常率的16.67%;Y染色体结构异常25例,占异常率的83.33%。检出45,X0/46,XY嵌合体4例;罗伯逊易位45,X,-Y,-13,+t(Y;13)(p1;q10)1例;大Y11例;小Y14例。结论:Y染色体异常对男性生育力有重要影响。
|
| 关 键 词： | Y染色体异常 男性不育 遗传效应 |
| 文章编号： | 1001-4411（2007）35-5011-03 |
| 修稿时间： | 2007-10-08 |
Clinical and genetic analysis on the influence of Y chromosome abnormality on male reproductive ability |
| |
| GAO Jiu - Chun, QI Cong - Yang , ZHENG Xian - Hong, et al. Clinical and genetic analysis on the influence of Y chromosome abnormality on male reproductive ability[J]. Maternal and Child Health Care of China, 2007, 22(35): 5011-5013 |
| |
| Authors: | GAO Jiu - Chun QI Cong - Yang ZHENG Xian - Hong et al |
| |
| Abstract: | Objective:To investigate the influence of Y chromosome abnormality on male reproductive ability.Methods:1 656 consultative patients were performed by peripheral blood lymphocytes culturing to make chromosome G-banding and analyze the karyotype by standard techniques.Results:30 cases of Y chromosome abnormality were observed in 1 656 patients,abnormal chromosome rate was 1.81%(30/1 656).Among the 30 cases,5 cases of numeric aberrations were found,accounting for 16.67%;25 cases of structural aberrations were found,accounting for 83.33%,including 4 cases of 45,XO mosaic 46,XY;1 cases of Robertsonian translocation 45,X,-Y,-13, t(Y;13)(p1;q10);11 cases of big Y chromosome abnormality;14 cases of small Y chromosome abnormality.Conclusion:Chromosome abnormality is an important factor resulting in male reproductive ability. |
| |
| Keywords: | Y chromosome abnormality Male infertility Genetic effect |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
