| 温肾方对实验性自身免疫性甲状腺炎大鼠白细胞介素-1α表达的影响 |
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| 引用本文： | 曹晓蕾,顾志峰,余江毅,秦文浩,崔世维.温肾方对实验性自身免疫性甲状腺炎大鼠白细胞介素-1α表达的影响[J].中国交通医学杂志,2006,20(1):45-46,48. |
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| 作者姓名： | 曹晓蕾 顾志峰 余江毅 秦文浩 崔世维 |
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| 作者单位： | [1]南通大学基础医学院病理解剖学教研室,江苏226001 [2]南通大学附属医院内分泌科,江苏226001 [3]江苏省中医院内分泌科,江苏226001 |
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| 基金项目： | 江苏省科技厅推广项目;江苏省人事厅资助项目 |
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| 摘 要： | 目的:研究温肾方对大鼠实验性自身免疫性甲状腺炎(EAT)白细胞介素-1(IL-1)的影响。方法:通过RT-PCR方法对SD大鼠EAT甲状腺组织IL-1进行测定,了解温肾方等对EAT的干预机制。结果:EAT大鼠的IL-1水平明显高于温肾方组、雷公藤组、对照组(P<0.05)。结论:温肾方可能通过对IL-1的抑制而对EAT起到预防及治疗作用。
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| 关 键 词： | 实验性自身免疫性甲状腺炎 细胞因子 白细胞介素-1 |
Effect of wenshenfang on the relative expression of IL-1α in experimental autoimmune thyroiditis |
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| Cao Xiaolei,Gu Zhifeng,Yu Jiangyi,Qin Wenhao,Cui Shiwei.Effect of wenshenfang on the relative expression of IL-1α in experimental autoimmune thyroiditis[J].Chinese Medical JOurnal of Communications,2006,20(1):45-46,48. |
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| Authors: | Cao Xiaolei Gu Zhifeng Yu Jiangyi Qin Wenhao Cui Shiwei |
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| Institution: | Basic Medical College of Nantong University,Jiangsu226001 |
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| Abstract: | Objective:To Investigate the effect of Wenshenfang in the treatment of experimental autoimmune thyroiditis(EAT) by observing IL-1 in thyroid tissues. Methods: EAT model was established in SD rats by injection of swine thyroglobin combined with adjuvant. Its mechanism was studied by detection of the relative expressions of IL-1. Result: The relative expressions of IL-1 were fewer in normal controls and the rats treated with Tripterygium Wilfordii Hook for Wenshenfang than in EAT rats without treatment (P<0.05).Conclusion: Wenshenfang has a therapeutic effect on EAT. The mechanism by which Wenshenfang exerts its effects may be by the suppression of relative expressions of IL-1 in thyroid cells. |
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| Keywords: | Experimental autoimmune thyroiditis Cytokine IL-1 |
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