脑外伤后迟发性脑梗塞患者急性期纤溶状态研究

目的初步探讨脑外伤后迟发性脑梗塞患者急性期血浆及脑脊液凝血纤溶状态变化,为临床脑外伤后迟发性脑梗塞提供诊治依据。方法脑外伤后迟发性脑梗塞患者72例,采集血浆,同时采集脑脊液,测定脑脊液及血浆部分凝血纤溶指标,并与171例脑外伤后无脑梗塞患者对照进行比较。结果脑外伤后迟发性脑梗塞组(实验组)脑脊液及血浆组织型纤溶酶原激活物(t-PA)、D-二聚体(D-D)含量明显高于非脑梗塞组(对照组)(P<0.01)而纤溶酶原(PLG)活性明显下降(P<0.01)。结论脑外伤后迟发性脑梗塞患者急性期存在明显的高凝状态和继发性纤溶活性增高。

Study on coagulation and fibrinolysis in patients with late cerebral infarction after acute brain injury

Objective To investigate the concentration of D-dimer(D-D), tissue-type plasminogen activator (t-PA) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with late cerebral infarction after acute brain injury and to probe their clinical significance.Methods The concentration of D-dimer and t-PA in plasma and cerebrospinal fluid in patients with late cerebral infarction after acute brain injury were examined by enzyme linked-immunosorbent assay (ELISA) and the measurement for PLG biological activity was performed by the chromophore method. All these results were compared with those of patients in control group.Results The concentrations of D-dimer and t-PA in patients with late cerebral infarction after acute brain injury were much higher than those in patients without cerebral infarction (P<0.01), while the PLG activity was significantly lower in the former (P<0.01).Conclusion Hypercoagulability and secondary hyperfibrinolysis exist in patients with late cerebral infarction after acute brain injury . And these hematological markers have clinica1 significance.