1431株结核分枝杆菌原发耐药性分析

目的了解广东省结核分枝杆菌临床分离株的原发耐药性情况,为今后结核病防治工作提供参考依据。方法采用WHO推荐的结核病耐药性监测的药敏比例法,对1431例从未用过抗结核药物的临床分离株进行耐药性测定。结果总原发耐药率为17.7%;4种一线常用抗结核药物的原发耐药率分别为:异烟肼(H)11.5%、链霉素(S)8.9%、利福平(R)7.1%、乙胺丁醇(E)3.6%。耐多药〔MDR〕78株,占5.5%。结论要重视化疗原则和加强管理水平,进一步减少耐药病例的发生。

Analyse for Primary Drug-resistance of 1431 Cases With Pulmonary Tuberculosis in Guangdong Orovince

Objective To know the primary drug-resistance of Mycobacterium tuberculosis in Guangdong province, and to provide reference for tuberculosis control. Methods Drugs resistance surveillance was implemented in Guangdong province according to the guidelines recommending by WHO. And proportional method was used in the surveillance. Results The rate of primary resistance for all was 17.7%, and the rates of INH, SM, REP and EMB were 11.5%, 8.9%, 7.1% and 3.6%. There were 78 cases with multi-drug resistance, accounting for (5.5%). Conclusions More attention should be made to according to the principle of standardize chemotherapy regimens and strengthening the management of chemotherapy ,in order to reduce the level of drug-resistance.