依达拉奉在不同注射液中配伍稳定性的研究

目的考察依达拉奉注射液分别与0．9％氯化钠注射液、葡萄糖氯化钠注射液、5％葡萄糖注射液、10％葡萄糖注射液配伍的稳定性。方法应用高效液相色谱仪测定依达拉奉注射液中的含量，考察依达拉奉注射液与常用注射液配伍后的pH值的变化。结果与4种注射液配伍后8h内，其外观无变化，但pH值、含量在1h后有显著变化。结论此4种输液于20℃下配伍，绝不能在1h外使用，1h内使用临床上也需谨慎观察。

Stability of edaravone injection mixed with 4 infusions

Objective To test the stability of edaravone injection mixed with 4 infusions. Methods Edaravone injection was mixed with 0, 9% saline infusion,glucose- saline infusion,5%and 10%glucose infusions at 20℃ respectively,within 8h after which the changes of appearance and pH value of the mixture solutions were observed. It was determined by HPLC. Results There are significant changes in pH value of the mixture solutions and contents in them after lb. Conclusion Edaravone injection can be mixed with the above-mentioned 4 infusions for clinical use within 1 h at 20℃.