4328例小儿与成人肾小球疾病病理类型比较

目的：了解小儿和成人肾小球疾病病理类型的异同。方法：我院住院的小儿与成人以肾活检术确诊为肾小球疾病的患者4328例，对其病理类型进行比较，结果：PGN可见14种病理改变，小儿组中的4种类型（MsPGM、IgMN,EnP,MCD)明显多于成人组（均P＜0．01），成人组有7种类型（IgAN,MN,FSGS,MPGN,FGS,SGN,PSGN)明显多于小儿组（均P＜0．01）。SGN小儿以HPSN（85．0％）占大多数，其次为LN（8．6％）；成人以HFRS（31．7％）较多见，次为LN（30．2％）、HSPN（19．0％）。结论：PGN小儿组病理类型和病变程度均较成人组轻。SGN小组病理类型较少，而成人组的病理类型较复杂，与随年龄增长而继发性疾病增多有关。

Pathological Study in 4 328 Child and Adult Patients with Glomerulopathy

To investigate the differences of pathological change between children and adult patients with glomerulo-pathy. Methods: The pathological types of 4 328 child and adult patients with glomerulopathy diagnosed by biopsy were retrospectively analyzed. Results:There were 14 pathological types in PGN. The 4 pathological types (MsPGN, IgMN,EnP and MCD)in child were more than in adults(all P<0.01). The 7 pathological types(IgAN,MN,FSGS,MPGN,FGS,SGN and PSGN)in adults were more than in children(all P<0.01). In child patients with SGN,HSPN(85.0%) was most frequent, the second was LN(8.6%). In adult patients with SGN,HFRS(31.7%)was most frequent,other types were LN (30.2%)and HSPN( 19.0%). Conclusion:The pathologic type and change of PGN in children were higher than in adults. The pathologic type of SON in adults was more complex than in children, which was correlated to increase of age and secondary disease.