滑动加压万向锁定生物金属接骨板对骨折愈合影响的动物实验

目的：观察滑动加压万向锁定生物金属接骨板对山羊股骨愈合的影响。方法采用自身对照的方法，12只山羊的双侧股骨分别随机行滑动加压万向锁定生物金属接骨板和锁定板固定。术中保留骨折间隙2mm，术后4，8，12周分批处死动物，每批4只，其中1只截取固定骨段作组织学观察，另3只动物取出双侧股骨，行影像学观察及生物力学测试。结果①影像学观察：术后4周与8周滑动加压万向锁定生物金属接骨板组较锁定板组骨折线模糊、消失。术后12周，两种接骨板固定骨折断端均愈合良好。②力学实验：术后4周与8周滑动加压万向锁定生物金属接骨板组的抗扭力学强度均显著性大于锁定板组（配对t检验，P＜0．05）。术后12周，两种接骨板的抗扭力学强度之间差异无显著性。③组织学观察：术后4周及8周时滑动加压万向锁定生物金属接骨板组骨折愈合的速度及质量均优于锁定板组，术后12周，滑动加压万向锁定生物金属接骨板组出现成熟的骨单位，锁定板组为规整的板层骨结构，哈弗氏系统排列规整，出现较多明显的骨吸收腔。结论滑动加压万向锁定生物金属接骨板对骨折断端进行持续有效加压，骨折愈合速度和质量均优于传统接骨板，具有良好的生物力学性能。

To Discuss the Effects of the Sliding Pressure Universal Lock Biological Mental Plate on Goat Femur Healing by Animal Experiment

Objective To observe the effect of the sliding compression universal lock biological metal plate on goat femur heal -ing.Methods Using self-control contrast method ,the bilateral femur of 12 goats were fixed respectively random by the sliding compression u-niversal lock biological metal plate and locking plate .The Intraoperative fracture gap was 2mm,the goats were partial put to death in 4,8,12 weeks,each times were 4 goats,of which only 1 were for histological observation using fixed bone segments ,the other 3 goats were for imaging observation and biomechanical test after taking bilateral femur .Results ①Imaging observation：compared with the locking plates ,the fracture line of the sliding compression universal lock biological metal plate group was fuzzy ,disappear after 4 weeks and 8 weeks,the fracture end in both kinds of bone plate was good healing after 12 weeks.②Mechanics experiment：in postoperative 4 weeks and eight weeks ,the resistance torque strength of the sliding compression universal lock biological metal plate were significantly greater than the locking plate group （ matc-hing t test,P〈0.05）.In postoperative 12 weeks,the resistance torque strength of two groups had no significant difference .③Histological ob-servation：in postoperative 4 weeks and 8 weeks,the fracture healing rate and the quality in the sliding compression universal lock biological metal plate group were superior to locking plate group ,in postoperative 12 weeks,the mature bone unit appeared in the sliding compression u-niversal lock biological metal plate group .The locking plate showed neat lamellar bone structure ,haversian system arrangement neat and more obvious bone resorption cavity .Conclusion For the sliding compression universal lock biological metal plate ,continuous and effective com-pression on fracture,healing,speed and quality are superior to traditional plate fracture .