大鼠丘脑背内侧核的传出联系——WGA-HRP法研究

将WGA-HRP微电泳导入19只大鼠的丘脑背内侧核(DM),又将WGA-HRP注射于17只大鼠前额叶皮质的前扣带回背部,前边缘叶和岛叶无颗粒皮质背部,观察DM的传出投射。 DM投射到前额叶皮质的范围广泛,并有一定的局部定位。DM外侧部主要投射到前扣带回背部,其次为中央前区内侧皮质、前边缘叶、岛叶无颗粒皮质背部及腹外侧眶区等。DM内侧部主要投射到岛叶无颗粒皮质背部,其次为前边缘叶、下边缘叶、内侧眶区及腹侧眶区等。DM中间部主要投射到岛叶无颗粒皮质背部。 DM还投射到某些皮质下核团,如丘脑网状核、外侧视前区、尾壳核、伏隔核、苍白球、丘脑下部外侧区及束旁核等。此外,DM和前额叶皮质的前扣带回背部、中央前区内侧皮质、前边缘叶、下边缘叶及岛叶无颗粒皮质背部以及和丘脑网状核、外侧视前区及丘脑下部外侧区之间均有交互投射。

EFFERENT CONNECTIONS OF THE DORSOMEDIAL NUCLEUS OF THALAMUS IN THE RAT WITH WGA-HRP METHOD

WGA-HRP was injected into the dorsomedial nucleus of thalamus (DM)by means of microiontophoretical delivery in 19 rats, and into the dorsal division of anterior cingulate cortex (ACd), the prelimbic area (PL), the dorsal agranular insular area (AId) of prefrontal cortex by using microinjective system in 17 rats to observe the efferent projections of the DM.It was found that the DM projected to a large part of the prefrontal cortex including the medial precentral area (PCm), ACd, PL, AId, ventral agranular insular area (AIv), medial orbital area (MO), ventral orbital area (VO), ventrolateral orbital area (VLO), and some topographical organizations were also found. The lateral segment of DM projects to the ACd, PCm, PL, AId, AIv and VLO. The intermediate segment of DM projects to the AId and AIv. The medial segment of DM projects to the AId, PL, IL, AIv, MO and VO. Furthermore, the DM also projects to some subcortical nuclei, such as the reticular nucleus of thalamus (R), the lateral preoptic area (LPO), the lateral hypothalamic area (LHA), the caudoputamen, the nucleus accumbens and the parafascicular nucleus of thalamus. In addition, some reciprocal connections between the DM and the ACd, PCm, PL, IL, AId, R, LPO and LHA were observed.