Central catecholamine,sympathetic nerve and vascular protein in the acute phase of two-kidney,one-clip renovascular hypertension in rats |
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Authors: | H. Kaneko T. Nakada |
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Affiliation: | (1) Department of Urology, Yamagata University, School of Medicine, Yamagata, Japan |
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Abstract: | Incorporation of3H-proline into the non-collagenous protein in mesenteric arteries in two-kidney, one-clip hypertensive rats was greater than that in normotensive rats. Splanchnicotomy predominantly over the root of mesenteric arteries or intracranioventricular injection of 6-hydroxydopamine prevented the development of hypertension in 2K-1C rats concomitant with the reduction of incorporation of3H-proline into the non-collagenous protein in mesenteric arteries. The content of norepinephrine in the hypothalamus in 2K-1C rats was lower than that in normotensive control rats. These findings indicate that increased non-collagenous protein synthesis in mesenteric arteries or low level of hypothalamic norepinephrine has facilitative effects on the development of 2K-1C hypertension. |
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