替米沙坦对老年高血压病患者脉压的影响

目的：探讨血管紧张素Ⅱ的Ⅰ型受体拮抗剂（ARB1）替米沙坦对老年高血压病患者脉压的影响。方法：符合WHO／ISH高血压病诊断标准的高血压病Ⅰ、Ⅱ级患者90例，治疗组56例。口服替米沙坦40～80mg，1次／d；对照组34例，口服赖诺普利5～10mg，1次／d。结果：用药半年后替米沙坦组，赖诺普利组收缩压（SBP）、舒张压（DBP）均显著下降（P分别〈0．001，〈0．01）、替米沙坦组脉压（PP）亦有明显缩小（P〈0．01）。结论：替米沙坦不仅是安全可靠的降压药，而且还可以缩小脉压，具有器官保护作用，可作为老年高血压一线用药。

Effects of telmisartan on pulse pressure in aged patient with hypertension

Objective:To evaluate the effects of telmisartan on pulse pressure in aged patient with hypertension.Methods:A total of 90 cases with hypertensive disease were definitely diagnosed according to WHO criterion.In 56 cases were administered telmisartan orally 40~80mg per day for six months;lisinopril treatment of 34 cases used as control .Results:After six months in telmisartan group and lisinopril group the SBP, DBP all decreased significantly,P< 0.001,<0.01 respectively;PP significantly decreased(P<0.01) in telmisartan group.Conclusion:Telmisartan is not only safe and effective in treating hypertension but also decreases pulse pressure. It can protect cardio-cerebro-renal function and be used as an antihypertensive drug in first consideration.