| 急性白血病细胞周期调节因子的表达及意义 |
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| 引用本文： | 梁翠微,龚五星,曲亚丽,黄翠珍,陈晖. 急性白血病细胞周期调节因子的表达及意义[J]. 重庆医学, 2011, 40(18). DOI: 10.3969/j.issn.1671-8348.2011.18.003 |
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| 作者姓名： | 梁翠微 龚五星 曲亚丽 黄翠珍 陈晖 |
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| 作者单位： | 暨南大学附属第三医院/珠海市人民医院血液肿瘤科,广东珠海,519000;暨南大学附属第三医院/珠海市人民医院血液肿瘤科,广东珠海,519000;暨南大学附属第三医院/珠海市人民医院血液肿瘤科,广东珠海,519000;暨南大学附属第三医院/珠海市人民医院血液肿瘤科,广东珠海,519000;暨南大学附属第三医院/珠海市人民医院血液肿瘤科,广东珠海,519000 |
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| 摘 要： | 目的 研究急性白血病患者骨髓细胞周期调控因子细胞S期激酶相关蛋白(Skp2)、P27、周期蛋白(cyclin) E 和Cyclin A1的表达及其临床意义.方法 将60例白血病患者分为初发组(n=41),复发组(n=9),完全缓解组(n=10),将非恶性血液病患者作为对照组(n=10).采用免疫细胞化学方法检测骨髓细胞Skp2、P27、Cyclin E 和Cyclin A1的表达,分析其表达与化疗疗效的关系.结果 急性白血病初发组及复发组Skp2、Cyclin E和Cyclin A1表达明显高于完全缓解组及对照组(P＜0.05),P27在初发组、完全缓解组及对照组的表达差异无统计学意义(P＞0.05),在复发组的表达较其他3组低(P＜0.05).急性白血病患者骨髓细胞Skp2、P27、Cyclin E和Cyclin A1阳性表达与患者年龄、性别、外周血乳酸脱氢酶水平无相关性(P＞0.05);Skp2与外周血白细胞计数呈正相关(P＜0.05);Skp2与完全缓解率呈负相关(P＜0.05),P27与其呈正相关(P＜0.05).Skp2和P27的比值比分别是0.076和6.842.结论 Skp2和P27可能是影响急性白血病化疗完全缓解率的独立预后因素.
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| 关 键 词： | 白血病 细胞周期蛋白类 S期激酶相关蛋白质类 |
The expression of cell cycle regulatory factors in acute leukemia and their clinical significance |
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| Liang Cuiwei,Gong Wuxing,Qu Yali,Huang Cuizhen,Chen Hui. The expression of cell cycle regulatory factors in acute leukemia and their clinical significance[J]. Chongqing Medical Journal, 2011, 40(18). DOI: 10.3969/j.issn.1671-8348.2011.18.003 |
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| Authors: | Liang Cuiwei Gong Wuxing Qu Yali Huang Cuizhen Chen Hui |
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| Affiliation: | Liang Cuiwei,Gong Wuxing,Qu Yali,Huang Cuizhen,Chen Hui(Department of Hematology and Oncology,Third Affiliated Hosptial,Jinan University/People's Hospital of Zhuhai,Zhuhai,Guangzhou 519000,China) |
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| Abstract: | Objective To study the expression of cell cycle regulatory factors such as S-phase kinase-associated protein 2(Skp2),P27,Cyclin E and Cyclin A1 in bone marrow cells of patients with acute leukemia and their clinical significance.Methods 60 cases of leukemia were divided into initial disease group(n=41),recurrence group(n=9) and complete remission group(n=10),and patients with non-malignant hematologic diseases served as control group(n=10).Immunocytochemistry was employed to detect the expression of Skp2,P2... |
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| Keywords: | leukemia cyclins S-phase kinase-associated proteins |
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