| 苏拉明联合紫杉醇对LA795肺腺癌小鼠移植瘤生长的抑制作用及机制 |
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| 引用本文： | 欧立文,贺兼斌,邓琼,张平. 苏拉明联合紫杉醇对LA795肺腺癌小鼠移植瘤生长的抑制作用及机制[J]. 重庆医学, 2011, 40(18): 1772-1774,1873. DOI: 10.3969/j.issn.1671-8348.2011.18.002 |
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| 作者姓名： | 欧立文 贺兼斌 邓琼 张平 |
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| 作者单位： | 欧立文,邓琼,Ou Liwen,Deng Qiong(湘南学院附属医院呼吸内科,湖南郴州,423000);贺兼斌,He Jianbin(怀化市第一人民医院呼吸内科,湖南怀化,418000);张平,Zhang Ping(南华大学附属第一医院呼吸内科,湖南衡阳,421001) |
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| 基金项目： | 湖南省卫生厅科研基金资助项目 |
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| 摘 要： | 目的观察苏拉明联合紫杉醇对LA795肺腺癌小鼠移植瘤生长的抑制作用,并探讨其作用机制。方法将32只皮下接种LA795肺腺癌细胞T739小鼠随机分为对照组、紫杉醇组、苏拉明组和联合组,每组8只。观察移植瘤生长情况,饲养24 d后处死小鼠,剥离皮下移植瘤,采用免疫组化检测移植瘤组织中血管生成素-2(Ang-2)和微血管密度(MVD)。结果紫杉醇组、苏拉明组和联合组移植瘤的生长明显受到抑制,以联合组生长最慢。对照组移植瘤质量大于其他3组(P<0.05)。紫杉醇组和苏拉明组移植瘤质量大于联合组(P<0.05);苏拉明组、紫杉醇组及联合组的抑瘤率分别为22.638%、25.629%及54.109%,其Q值为1.274(>1.15)。苏拉明组和联合组移植瘤组织内Ang-2的表达均低于对照组和紫杉醇组(P<0.05)。对照组移植瘤组织内MVD高于其他3组(P<0.05);紫杉醇组或苏拉明组移植瘤组织内MVD高于联合组(P<0.05)。移植瘤组织中Ang-2表达、MVD与移植瘤质量均呈正相关(r=0.468、0.526,P<0.01)。结论苏拉明可下调肿瘤组织Ang-2表达,抑制肿瘤内微血管形成,与紫杉醇联合对LA795肺腺癌小鼠皮下移植瘤生长发挥协同抑制作用。
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| 关 键 词： | 腺癌 移植,同种 小鼠 苏拉明 紫杉醇 |
Inhibitory effects of suramin combined with paclitaxel on growth of transplanted LA795 lung adenocarcinoma in mice and its mechanism |
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| Ou Liwen,He Jianbin,Deng Qiong,Zhang Ping. Inhibitory effects of suramin combined with paclitaxel on growth of transplanted LA795 lung adenocarcinoma in mice and its mechanism[J]. Chongqing Medical Journal, 2011, 40(18): 1772-1774,1873. DOI: 10.3969/j.issn.1671-8348.2011.18.002 |
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| Authors: | Ou Liwen He Jianbin Deng Qiong Zhang Ping |
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| Affiliation: | Ou Liwen1,He Jianbin2,Deng Qiong1,Zhang Ping3(1.Department of Respiratory Medicine,Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,China,2.Department of Respiratory Medicine,First People's Hospital of Huaihua,Huaihua,Hunan 418000,3.Department of Respiratory Medicine,First Affiliated Hospital of Nanhua University,Hengyang,Hunan 421001,China) |
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| Abstract: | Objective To observe the inhibitory effect of suramin combined with paclitaxel on growth of transplanted LA795 lung adenocarcinoma in mice and explore its mechanism.Methods 32 T739 mice inoculated subcutaneously with LA795 lung adenocarcinoma cells were randomly divided into the control,paclitaxel,suramin and combination group,with 8 mice in each group.The growth of transplanted carcinoma were observed.Mice were sacrificed after 24 d feeding,and then the subcutaneous transplanted carcinoma were peeled.Angio... |
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| Keywords: | adenocarcinoma transplantation homologous mice suramin paclitaxel |
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